{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:26:06Z","timestamp":1774063566006,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"62","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/01\/CEIB\/II\/V\/13"],"award-info":[{"award-number":["BT\/01\/CEIB\/II\/V\/13"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2017,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new series of tertiary\u2010butyl ammonium (<jats:bold>TBA<\/jats:bold>) salts of various nonsteroidal anti\u2010inflammatory drugs (NSAIDs) have been synthesized and characterized. Nearly 90\u2009% of the NSAID\u2010derived primary ammonium monocarboxylate (PAM) salts displayed remarkable gelation ability with various solvents including methyl salicylate. Single crystal X\u2010ray diffraction data (SXRD) revealed the existence of 1D\u2005PAM synthon in the gelator salts. Structure\u2013property correlation studies based on SXRD and powder X\u2010ray diffraction (PXRD) data established the presence of the 1D\u2005PAM synthon in the bulk salts as well as in the corresponding xerogels. A parallel series of salts derived from <jats:bold>TRIS<\/jats:bold> (2\u2010amino\u20102\u2010(hydroxymethyl)\u20101,3\u2010propanediol) and the same set of NSAIDs displayed poor gelation ability; only 33\u2009% of the salts in the series displayed gelation ability. A few selected gelator salts of both <jats:bold>TBA<\/jats:bold> and <jats:bold>TRIS<\/jats:bold> were found to be biocompatible (MTT assay with RAW\u2005264.7 cell line) and two of the selected salts (<jats:bold>FLR.TBA<\/jats:bold> and <jats:bold>FLR.TRIS<\/jats:bold>) possessed anti\u2010inflammatory properties equal to the parent drug <jats:bold>FLR<\/jats:bold> (flurbiprofen). Finally a methyl salicylate topical gel derived from <jats:bold>FLR.TRIS<\/jats:bold> was successfully delivered in a self\u2010delivery fashion to treat inflamed skin conditions in the mice model. Histological studies of the dorsal tissues of the untreated and treated mice clearly demonstrated the effect of topical gels in such treatment.<\/jats:p>","DOI":"10.1002\/chem.201703850","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T02:18:11Z","timestamp":1505182691000},"page":"15623-15627","source":"Crossref","is-referenced-by-count":12,"title":["Supramolecular Synthon Approach in Developing Anti\u2010Inflammatory Topical Gels for In\u2005Vivo Self\u2010Delivery"],"prefix":"10.1002","volume":"23","author":[{"given":"Rajdip","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Indian Association for the Cultivation of Science (IACS)  2A and 2B, Raja\u2005S.\u2005C. 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