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Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two\u2010dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label\u2010free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS<jats:sub>2<\/jats:sub> presents different modulating effects on the assembly of amyloid\u2010\u03b2 peptide (33\u201342) [A\u03b2\u2005(33\u201342)] and amylin (20\u201329), mainly owing to the distinct affinity between amyloid peptides and MoS<jats:sub>2<\/jats:sub>. This is to our knowledge the first report of MoS<jats:sub>2<\/jats:sub> as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self\u2010assembly of amyloid peptides, and expands the applications of MoS<jats:sub>2<\/jats:sub> in biology.<\/jats:p>","DOI":"10.1002\/chem.201704593","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T01:36:39Z","timestamp":1512524199000},"page":"3397-3402","source":"Crossref","is-referenced-by-count":34,"title":["Differential Modulating Effect of MoS<sub>2<\/sub> on Amyloid Peptide Assemblies"],"prefix":"10.1002","volume":"24","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Institute for Advanced Materials Jiangsu University  212013 Xuefu Road No. 301 Zhenjiang city Jinagsu Province P.R. 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