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Existing glycoconjugate vaccines based on purified capsular polysaccharides are widely used and help to prevent millions of deaths every year. Herein, the total syntheses of oligosaccharides resembling portions of the <jats:italic>S. pneumoniae<\/jats:italic> serotype 7F (ST7F) capsular polysaccharide repeating unit are reported. To define minimal glycan epitopes, glycan microarrays containing the synthetic oligosaccharides were used to screen human reference serum and revealed that both side chains of the ST7F play a key role in antigen recognition. The identification of protective minimal epitopes is vital to design efficient semi\u2010 and fully\u2010synthetic glycoconjugate vaccines.<\/jats:p>","DOI":"10.1002\/chem.201705379","type":"journal-article","created":{"date-parts":[[2018,1,14]],"date-time":"2018-01-14T21:52:43Z","timestamp":1515966763000},"page":"4181-4187","source":"Crossref","is-referenced-by-count":21,"title":["Identification of the Minimal Glycotope of <i>Streptococcus pneumoniae<\/i> 7F Capsular Polysaccharide using Synthetic Oligosaccharides"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-194X","authenticated-orcid":false,"given":"Petra","family":"M\u00e9nov\u00e1","sequence":"first","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interphases  Am M\u00fchlenberg 1 14476 Potsdam Germany"},{"name":"Present address: University of Chemistry and Technology  Technick\u00e1 5 166 28 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Sella","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interphases  Am M\u00fchlenberg 1 14476 Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sellrie","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interphases  Am M\u00fchlenberg 1 14476 Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1972-7907","authenticated-orcid":false,"given":"Claney L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interphases  Am M\u00fchlenberg 1 14476 Potsdam Germany"},{"name":"Present address: Vaxxilon (Deutschland) GmbH  Magnusstra\u00dfe\u200511 12489 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-8466","authenticated-orcid":false,"given":"Peter H.","family":"Seeberger","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interphases  Am M\u00fchlenberg 1 14476 Potsdam Germany"},{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Arnimallee\u200522 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00024-15"},{"key":"e_1_2_7_2_1","unstructured":"ECDC Annual Epidemiological Report2016 http:\/\/ecdc.europa.eu\/en\/healthtopics\/pneumococcal_infection\/Pages\/Annual-epidemiological-report-2016.aspx; 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