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The reaction is modulated by the electronic properties of the substituents on both indoles, with the 2,3\u2032\u2010BIMs favoured when electron donating groups are present. Although simple at first, a complex mechanism has been uncovered that explains the different behaviour of these systems with platinum when compared with other metals (e.g. gold). Detailed labelling studies have shown Pt\u2010catalysed 6\u2010<jats:italic>endo\u2010trig<\/jats:italic> cyclisation of the indollylallene as the first step of the reaction and the involvement of two cyclic vinyl\u2010platinum intermediates in equilibrium through a platinum carbene, as the key intermediates of the catalytic cycle towards the second nucleophilic attack and formation of the BIMs.<\/jats:p>","DOI":"10.1002\/chem.201705417","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T06:43:03Z","timestamp":1517553783000},"page":"6105-6114","source":"Crossref","is-referenced-by-count":16,"title":["Synthesis of a Novel Type of 2,3\u2032\u2010BIMs via Platinum\u2010Catalysed Reaction of Indolylallenes with Indoles"],"prefix":"10.1002","volume":"24","author":[{"given":"Lisa","family":"Cooper","sequence":"first","affiliation":[{"name":"School of Chemistry University of East Anglia  Earlham Road Norwich NR4 7TJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Miguel","family":"Alonso","sequence":"additional","affiliation":[{"name":"School of Chemistry University of East Anglia  Earlham Road Norwich NR4 7TJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Eagling","sequence":"additional","affiliation":[{"name":"School of Chemistry University of East Anglia  Earlham Road Norwich NR4 7TJ UK"},{"name":"Novartis Pharmaceuticals (UK) Limited  RH12 5AB, Horsham West Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Newson","sequence":"additional","affiliation":[{"name":"School of Chemistry University of East Anglia  Earlham Road Norwich NR4 7TJ UK"},{"name":"Novartis Pharmaceuticals (UK) Limited  RH12 5AB, Horsham West Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachini","family":"Herath","sequence":"additional","affiliation":[{"name":"School of Chemistry University of East Anglia  Earlham Road Norwich NR4 7TJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Thomson","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals (UK) Limited  RH12 5AB, Horsham West Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Lister","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals (UK) Limited  RH12 5AB, Horsham West Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Howsham","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals (UK) Limited  RH12 5AB, Horsham West Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Cox","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals (UK) Limited  RH12 5AB, Horsham West Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-349X","authenticated-orcid":false,"given":"Mar\u00eda Paz","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"School of Chemistry University of East Anglia  Earlham Road Norwich NR4 7TJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr2003954"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.04.012"},{"key":"e_1_2_7_4_2","first-page":"2249","volume":"2","author":"Kumar L.","year":"2012","journal-title":"Int. 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