{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:52:28Z","timestamp":1789145548318,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2018,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The first total synthesis of the potent antibiotic disciformycin\u2005B (<jats:bold>2<\/jats:bold>) is described, which is exceptionally isomerization\u2010prone and transforms into disciformycin\u2005A (<jats:bold>1<\/jats:bold>) even under notably mild conditions. To outweigh this bias, the approach to <jats:bold>2<\/jats:bold> hinged on the use of a silyl residue at C4 to lock the critical double bond in place and hence insure the integrity of the synthetic intermediates en route to <jats:bold>2<\/jats:bold>. This tactic was instrumental for the preparation of the building blocks and formation of the macrocyclic ring via ring closing alkyne metathesis (RCAM). To make the end game successful, however, it proved necessary to cleave the C\u2010silyl protecting group off; it was at this stage that the exceptional sensitivity of the target became fully apparent.<\/jats:p>","DOI":"10.1002\/chem.201705550","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T09:52:45Z","timestamp":1511344365000},"page":"109-114","source":"Crossref","is-referenced-by-count":51,"title":["Total Synthesis of Disciformycin\u2005A and B: Unusually Exigent Targets of Biological Significance"],"prefix":"10.1002","volume":"24","author":[{"given":"Yonghoon","family":"Kwon","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung  45470 M\u00fclheim\/Ruhr Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Schulthoff","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung  45470 M\u00fclheim\/Ruhr 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