{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:02:30Z","timestamp":1787320950369,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["103-2113-M-005-008-MY3"],"award-info":[{"award-number":["103-2113-M-005-008-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2113-M-005-015-MY3"],"award-info":[{"award-number":["104-2113-M-005-015-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Photodynamic therapy (PDT) is a promising and minimally invasive method for the treatment of superficial diseases, and photosensitizers with high phototoxicity indices (defined as (IC\n                    <jats:sub>50<\/jats:sub>\n                    <jats:sup>dark<\/jats:sup>\n                    )\/(IC\n                    <jats:sub>50<\/jats:sub>\n                    <jats:sup>irradiation<\/jats:sup>\n                    )) are essential for the development of ideal photosensitizing properties for this technology. Herein, we report a series of photocytotoxic copper(II) complexes [Cu(\n                    <jats:sup>R<\/jats:sup>\n                    <jats:bold>QYMP<\/jats:bold>\n                    )(dppn)] (\n                    <jats:sup>R<\/jats:sup>\n                    <jats:bold>QYMP<\/jats:bold>\n                    =\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>O<\/jats:italic>\n                    \u2010tridentate Schiff\u2010base derivatives, dppn=benzo[\n                    <jats:italic>i<\/jats:italic>\n                    ]dipyrido[3,2\u2010\n                    <jats:italic>a<\/jats:italic>\n                    ;2\u2032,3\u2032\u2010\n                    <jats:italic>c<\/jats:italic>\n                    ]phenazine), the structures of which have been confirmed by mass spectrometry and FTIR spectroscopy. X\u2010ray crystallography revealed that the CuN\n                    <jats:sub>4<\/jats:sub>\n                    O core of the [Cu(\n                    <jats:sup>cumyl<\/jats:sup>\n                    <jats:bold>QYMP<\/jats:bold>\n                    )(dppn)](ClO\n                    <jats:sub>4<\/jats:sub>\n                    ) complex (\n                    <jats:bold>3<\/jats:bold>\n                    ) has a distorted square\u2010pyramidal geometry. Phototoxicity indices of 329 against human squamous cell carcinoma (SCC15) and 296 against basal cell carcinoma (BCC) cell lines have been determined with [Cu(\n                    <jats:sup>3\u2010OMe<\/jats:sup>\n                    <jats:bold>QYMP<\/jats:bold>\n                    )(dppn)](ClO\n                    <jats:sub>4<\/jats:sub>\n                    ) (\n                    <jats:bold>4<\/jats:bold>\n                    ). This can be attributed to the formation of reactive oxygen species, cell apoptosis, and caspase\u20103 activation, indicating high potential of complex\n                    <jats:bold>4<\/jats:bold>\n                    as a photosensitizer candidate in PDT. Thus, copper complexes bearing suitable Schiff\u2010base ligands with a dppn co\u2010ligand may be considered for the design of efficient metal\u2010based anticancer agents for PDT.\n                  <\/jats:p>","DOI":"10.1002\/chem.201705640","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T06:03:02Z","timestamp":1512799382000},"page":"4111-4120","source":"Crossref","is-referenced-by-count":48,"title":["Photocytotoxic Copper(II) Complexes with Schiff\u2010Base Scaffolds for Photodynamic Therapy"],"prefix":"10.1002","volume":"24","author":[{"given":"Rong\u2010Kai","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Chemistry National Chung Hsing University  No. 250, Kuo-Kuang Road Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010I","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Chung Hsing University  No. 250, Kuo-Kuang Road Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho\u2010Han","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Chung Hsing University  No. 250, Kuo-Kuang Road Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ju","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Chung Hsing University  No. 250, Kuo-Kuang Road Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parthiban","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Chung Hsing University  No. 250, Kuo-Kuang Road Taichung 402 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Chung Hsing University  No. 250, Kuo-Kuang Road Taichung 402 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