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Battling <jats:italic>H.\u2005pylori<\/jats:italic> infection is a serious challenge due to the increased resistance to antibiotics and the lack of vaccines. The lipopolysaccharide covering the <jats:italic>H.\u2005pylori<\/jats:italic> cell\u2010surface outer membrane is an attractive target for the development of a glycoconjugate vaccine. Here, we report a [3+5] convergent synthesis of an outer core octasaccharide of <jats:italic>H.\u2005pylori<\/jats:italic> employing just three orthogonally protected building blocks. A synergistic glycosylation strategy enables the creation of five pivotal 1,2\u2010<jats:italic>cis<\/jats:italic>\u2010\u03b1\u2010glucosidic bonds consist of four types of linkages using just three monomers. 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