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In this study, we demonstrate the morphology\u2010dependent enzyme mimetic activity of Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles. It is found that Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles mimic the functions of all three cellular antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Interestingly, the nanozyme activity of Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    depends on various factors including size, morphology, surface area, and the redox properties of the metal ions. The Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoflowers exhibited remarkably high activity in all three enzyme systems and the order of multienzyme activity of different morphologies was: flowers \u226b flakes &gt; hexagonal plates\u2248polyhedrons\u2248cubes. Interestingly, all five nanoforms are taken up by the mammalian cells and were found to be biocompatible, with very low cytotoxicity. The activity of the most active nanoflowers was studied in primary human umbilical vein endothelial cells (HUVEC) and human pulmonary microvascular endothelial cells (hPMEC) and it was found that Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    does not reduce the level of nitric oxide (NO). This is in contrast to the effect of some of the Mn\u2010porphyrin\u2010based SOD mimetics, which are known to scavenge NO in endothelial cells.\n                  <\/jats:p>","DOI":"10.1002\/chem.201800770","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T06:39:29Z","timestamp":1522478369000},"page":"8393-8403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Manganese\u2010Based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase"],"prefix":"10.1002","volume":"24","author":[{"given":"Namrata","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Inorganic and Physical Chemistry Indian Institute of Science  Bangalore- 560012 India"},{"name":"Center for Nanoscience and Engineering Indian Institute of Science  Bangalore- 560012 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