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Thermodynamic parameters, as for instance the copper(II) affinity of the drug candidate or the copper(II) over zinc(II) selectivity, are considered in the design of the drug candidate. In contrast, kinetic factors have been overlooked despite their probable high importance. In the present article, we use a series of azamacrocyclic ligands to demonstrate that kinetic issues must be taken into account when designing copper\u2010targeting drug candidates in the context of AD.<\/jats:p>","DOI":"10.1002\/chem.201801520","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T11:22:58Z","timestamp":1522754578000},"page":"8447-8452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Kinetics Are Crucial When Targeting Copper Ions to Fight Alzheimer's Disease: An Illustration with Azamacrocyclic Ligands"],"prefix":"10.1002","volume":"24","author":[{"given":"Amandine","family":"Conte\u2010Daban","sequence":"first","affiliation":[{"name":"CNRS, LCC (Laboratoire de Chimie de Coordination)  205 route de Narbonne BP 44099 31077 Toulouse Cedex 4 France"},{"name":"University of Toulouse, UPS, INPT  31077 Toulouse Cedex 4 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryline","family":"Beyler","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, UMR-CNRS 6521 CEMCA, IBSAM, UFR des Sciences et Techniques  6 avenue Victor le Gorgeu, C.S. 93837 29238 BREST Cedex 3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Tripier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, UMR-CNRS 6521 CEMCA, IBSAM, UFR des Sciences et Techniques  6 avenue Victor le Gorgeu, C.S. 93837 29238 BREST Cedex 3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-0239","authenticated-orcid":false,"given":"Christelle","family":"Hureau","sequence":"additional","affiliation":[{"name":"CNRS, LCC (Laboratoire de Chimie de Coordination)  205 route de Narbonne BP 44099 31077 Toulouse Cedex 4 France"},{"name":"University of Toulouse, UPS, INPT  31077 Toulouse Cedex 4 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1159\/000464422"},{"key":"e_1_2_7_2_1","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb400080f"},{"key":"e_1_2_7_4_2","unstructured":"E. 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