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Utilization of an N,N,O\u2010type coordination pocket along with an octahedral zinc(II) metal ion allowed us to obtain mono\u2010 and tetranuclear complexes in both solution and solid state, as confirmed by NMR spectroscopy and single\u2010crystal X\u2010ray diffraction, respectively. By using isothermal titration calorimetry and gel electrophoresis, multiply charged cationic assemblies were observed to effectively bind to DNA through multivalent electrostatic interactions. Furthermore, we observed a correlation between the multivalency of the compounds employed and the effectiveness of DNA binding.<\/jats:p>","DOI":"10.1002\/chem.201801552","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T13:40:04Z","timestamp":1525873204000},"page":"10802-10811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Multivalent Metallosupramolecular Assemblies as Effective DNA Binding Agents"],"prefix":"10.1002","volume":"24","author":[{"given":"Wojciech","family":"Dro\u017cd\u017c","sequence":"first","affiliation":[{"name":"Faculty of Chemistry Adam Mickiewicz University  Umultowska\u200589b 61-614 Pozna\u0144 Poland"},{"name":"Center for Advanced Technologies Adam Mickiewicz University  Umultowska\u200589c 61-614 Pozna\u0144 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