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Its current production entails problems concerning safety, prolonged reaction times and the use of excessive amounts of chlorinating reagents. We developed a continuous flow procedure for acid chloride formation from acrylic acid and a consecutive 1,4\u2010addition of hydrogen chloride generating 3\u2010chloropropionyl chloride, as presented in this paper. Up to 94\u2009% conversion was reached in 25\u2005minutes at mild temperatures and pressures. This continuous flow method offers a safer alternative and is highly efficient in terms of consumption of starting product and shorter residence time. Valorization of this building block is exemplified by the synthesis of beclamide, a compound with sedative and anticonvulsant properties. Over 80\u2009% conversion towards this drug was achieved in 1\u2005minute in a continuous flow setup. Further research is needed to telescope the synthesis of 3\u2010chloropropionyl chloride and subsequent beclamide formation without intermediate purification.<\/jats:p>","DOI":"10.1002\/chem.201802208","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T12:45:03Z","timestamp":1528375503000},"page":"11779-11784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atom\u2010 and Mass\u2010economical Continuous Flow Production of 3\u2010Chloropropionyl Chloride and its Subsequent Amidation"],"prefix":"10.1002","volume":"24","author":[{"given":"Marine","family":"Movsisyan","sequence":"first","affiliation":[{"name":"Department of Green Chemistry and Technology Ghent University  Coupure Links 653 9000 Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S. 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