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It has been found that different A\u03b2 species, including N\u2010terminal truncated or\/and modified A\u03b2, co\u2010exist in the brain of AD patients. Yet, there is currently little detailed work about the specific modulation of these A\u03b2 species which hinders us to understand their roles in patients\u2019 brain. Using thioflavin T (ThT) kinetics and transmission electron microscope, here we showed that cucurbit[7]uril and cucurbit[8]uril could inhibit the aggregation of both A\u03b2<jats:sub>4\u201040<\/jats:sub> and A\u03b2<jats:sub>1\u201040<\/jats:sub> through host\u2010guest interactions. Chemical kinetics analysis suggested that this happened through inhibiting the elongation process by binding with fibril ends. In addition, cucurbiturils showed greater capability on the inhibition of A\u03b2<jats:sub>4\u201040<\/jats:sub> than A\u03b2<jats:sub>1\u201040<\/jats:sub>, which was possibly due to the N\u2010terminal phenylalanine residue of A\u03b2<jats:sub>4\u201040<\/jats:sub>. Our work provided new insights for the development of host\u2013guest chemistry based inhibitors for the aggregation of different A\u03b2 species.<\/jats:p>","DOI":"10.1002\/chem.201802655","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T07:32:35Z","timestamp":1528961555000},"page":"13647-13653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Differential Modulation of the Aggregation of N\u2010Terminal Truncated A\u03b2 using Cucurbiturils"],"prefix":"10.1002","volume":"24","author":[{"given":"Gao","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  100084 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhou Pei-Yuan Center for Applied Mathematics Department of, Mathematical Sciences Tsinghua University  100084 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Fen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  100084 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  100084 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Hong","sequence":"additional","affiliation":[{"name":"Zhou Pei-Yuan Center for Applied Mathematics Department of, Mathematical Sciences Tsinghua University  100084 Beijing 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