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The target LOS mimics, consisting of eight or nine monosaccharides, were classified into three groups as key building blocks: ganglioside\u2010core tetra\u2010\/pentasaccharides (GM1\u2010\/GD1a\u2010like), <jats:sc>l<\/jats:sc>\u2010<jats:italic>glycero<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010<jats:italic>manno<\/jats:italic>\u2010heptose\u2010containing trisaccharides, and 3\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010<jats:italic>manno<\/jats:italic>\u20102\u2010octulosonic acid (KDO) residues. These synthetic fragments were obtained from commercially available monosaccharides. Less obtainable <jats:sc>l<\/jats:sc>\u2010<jats:italic>glycero<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010<jats:italic>manno<\/jats:italic>\u2010heptose and KDO residues, as key components of the LOSs, were synthesized from <jats:italic>p<\/jats:italic>\u2010methoxyphenyl <jats:sc>d<\/jats:sc>\u2010mannoside and di\u2010<jats:italic>O<\/jats:italic>\u2010isopropylidene\u2010protected <jats:sc>d<\/jats:sc>\u2010mannose, respectively. The synthesis of \u03b1\u2010KDO glycoside, as one of the most difficult stereocontrolled glycosidic constructions, was achieved by treating a 2,3\u2010ene derivative of KDO with phenylselenyl trifluoromethanesulfonate as a suitable \u03b1\u2010directing reagent. All synthetic blocks were constructed through a convergent synthetic route, which resulted in the first synthesis of structurally challenging LOS core glycans containing ganglioside GM1 and GD1a\u2010core sequences.<\/jats:p>","DOI":"10.1002\/chem.201804862","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T12:13:28Z","timestamp":1540296808000},"page":"796-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis of the Core Oligosaccharides of Lipooligosaccharides from <i>Campylobacter jejuni<\/i>: A Putative Cause of Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1002","volume":"25","author":[{"given":"Fumi","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshinaka","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Center for Highly Advanced Integration and Nano and Life Sciences, (G-CHAIN) Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hanashima","sequence":"additional","affiliation":[{"name":"Structural Glycobiology Team, Systems Glycobiology Research Group RIKEN Global Research Cluster  2-1 Hirosawa Wako Saitama 351-0198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Structural Glycobiology Team, Systems Glycobiology Research Group RIKEN Global Research Cluster  2-1 Hirosawa Wako Saitama 351-0198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Saburomaru","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromune","family":"Ando","sequence":"additional","affiliation":[{"name":"Center for Highly Advanced Integration and Nano and Life Sciences, (G-CHAIN) Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kiso","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-992X","authenticated-orcid":false,"given":"Akihiro","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Applied Bio-organic Chemistry Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"},{"name":"Center for Highly Advanced Integration and Nano and Life Sciences, (G-CHAIN) Gifu University  1-1 Yanagido Gifu-shi Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000324710"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70215-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270704"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/90935"},{"key":"e_1_2_7_6_1","first-page":"002063","author":"Hughes R. 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