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From then on several classes of zinc\u2010binders have been described. This work reports the benzenephosponamidates as a new chiral aromatic sulfonamide\u2010mimic ZBG able to meet the requirements for effectively binding the enzyme active site. Several low micromolar CA I, II, VII, IX inhibitors were thus detected. Kinetic studies, QM\u2010polarized ligand docking, and MM\u2010GBSA in silico methods were used to characterize this newly identified CA inhibitor chemotype.<\/jats:p>","DOI":"10.1002\/chem.201805039","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T06:09:25Z","timestamp":1541743765000},"page":"1188-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide\u2010Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors"],"prefix":"10.1002","volume":"25","author":[{"given":"Alessio","family":"Nocentini","sequence":"first","affiliation":[{"name":"Department NEUROFARBA-Pharmaceutical and nutraceutical section Laboratory of Molecular Modeling Cheminformatics &amp; QSAR University of Firenze  via Ugo Schiff 6 50019 Sesto Fiorentino Italy"},{"name":"Department NEUROFARBA\u2013Pharmaceutical and nutraceutical section University of Firenze  via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-2509","authenticated-orcid":false,"given":"Paola","family":"Gratteri","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA-Pharmaceutical and nutraceutical section Laboratory of Molecular Modeling Cheminformatics &amp; QSAR University of Firenze  via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA\u2013Pharmaceutical and nutraceutical section University of Firenze  via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.913587"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_2_4_1","volume-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, Part\u2005II","year":"2009"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1067685"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.08.015"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603112113"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.14.68"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc34275h"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300981b"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc16395k"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400414j"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00462"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC06399C"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.01.113"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1428572"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00393a026"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00400a008"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.03.023"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm1004754"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC05755A"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01354a010"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2014.08.002"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1508453"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1107\/S205252061700138X"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00828"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.201805039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201805039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.201805039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201805039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:34:10Z","timestamp":1760286850000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.201805039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,1,24]]}},"alternative-id":["10.1002\/chem.201805039"],"URL":"https:\/\/doi.org\/10.1002\/chem.201805039","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,14]]},"assertion":[{"value":"2018-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}