{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:23:27Z","timestamp":1787243007142,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 803"],"award-info":[{"award-number":["SFB 803"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2019,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    \u03b2\u2010Peptides are an interesting new class of transmembrane model peptides based on their conformationally stable and well\u2010defined secondary structures. Herein, we present the synthesis of the paramagnetic \u03b2\u2010amino acid \u03b2\n                    <jats:sup>3<\/jats:sup>\n                    \u2010hTOPP (4\u2010(3,3,5,5\u2010tetramethyl\u20102,6\u2010dioxo\u20104\u2010oxylpiperazin\u20101\u2010yl)\u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u2010\u03b2\n                    <jats:sup>3<\/jats:sup>\n                    \u2010homophenylglycine) that enables investigations of \u03b2\u2010peptides by EPR spectroscopy. This amino acid adds to the, to date, sparse number of \u03b2\u2010peptide spin labels. Its performance was evaluated by investigating the helical turn of a 3\n                    <jats:sub>14<\/jats:sub>\n                    \u2010helical transmembrane model \u03b2\u2010peptide. Nanometer distances between two incorporated \u03b2\n                    <jats:sup>3<\/jats:sup>\n                    \u2010hTOPP labels in different environments were measured by using pulsed electron\/electron double resonance (PELDOR\/DEER) spectroscopy. Due to the semi\u2010rigid conformational design, the label delivers reliable distances and sharp (one\u2010peak) distance distributions even in the lipid bilayer. The results indicate that the investigated \u03b2\u2010peptide folds into a 3.25\n                    <jats:sub>14<\/jats:sub>\n                    helix and maintains this conformation in the lipid bilayer.\n                  <\/jats:p>","DOI":"10.1002\/chem.201805880","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T11:16:11Z","timestamp":1543576571000},"page":"2203-2207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Semi\u2010Rigid Nitroxide Spin Label for Long\u2010Range EPR Distance Measurements of Lipid Bilayer Embedded \u03b2\u2010Peptides"],"prefix":"10.1002","volume":"25","author":[{"given":"Janine","family":"Wegner","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstrasse 2 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Valora","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie  Am Fassberg 11 37077 G\u00f6ttingen Germany"},{"name":"Dipartimento di Scienze Chimiche University of Catania  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Halbmair","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie  Am Fassberg 11 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Kehl","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstrasse 2 37077 G\u00f6ttingen Germany"},{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie  Am Fassberg 11 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Worbs","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstrasse 2 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bennati","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstrasse 2 37077 G\u00f6ttingen Germany"},{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie  Am Fassberg 11 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-9160","authenticated-orcid":false,"given":"Ulf","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstrasse 2 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja068678n"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/b101085i"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2675(20010815)84:8<2155::AID-HLCA2155>3.0.CO;2-8"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja963290l"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19960790402"},{"key":"e_1_2_2_7_1","volume-title":"EPR Spectroscopy, Fundamentals and Methods, EMagRes Bks","year":"2018"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03161886"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1944"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003358350700460X"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-032511-143716"},{"key":"e_1_2_2_13_2","first-page":"1","volume-title":"Structure and Bonding Vol. 152, Pulse Dipolar EPR: Distance Measurements","author":"Borbat P. 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