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The method demonstrated selectivity towards the 4\u2010position of pyrazolin\u20105\u2010ones even in the presence of NPh and allyl substituents, which are sensitive to nitration. It was shown that other systems containing Fe<jats:sup>III<\/jats:sup> and nitrites, namely Fe(NO<jats:sub>3<\/jats:sub>)<jats:sub>3<\/jats:sub>\/<jats:italic>t<\/jats:italic>BuONO, Fe(ClO<jats:sub>4<\/jats:sub>)<jats:sub>3<\/jats:sub>\/NaNO<jats:sub>2<\/jats:sub>, and Fe(ClO<jats:sub>4<\/jats:sub>)<jats:sub>3<\/jats:sub>\/<jats:italic>t<\/jats:italic>BuONO, were also effective. Presumably, Fe<jats:sup>III<\/jats:sup> oxidizes the nitrite (NaNO<jats:sub>2<\/jats:sub> or <jats:italic>t<\/jats:italic>BuONO) to form the NO<jats:sub>2<\/jats:sub> free radical, which serves as the nitrating agent for pyrazolin\u20105\u2010ones. The synthesized 4\u2010nitropyrazolin\u20105\u2010ones were discovered to be a new class of fungicides. Their in vitro activities against phytopathogenic fungi were found comparable or even superior to those of commercial fungicides (fluconazole, clotrimazole, triadimefon, and kresoxim\u2010methyl). These results represent a promising starting point for the development of a new type of plant protection agents that can be easily synthesized from widely available reagents.<\/jats:p>","DOI":"10.1002\/chem.201806172","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T22:15:33Z","timestamp":1551737733000},"page":"5922-5933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mild Nitration of Pyrazolin\u20105\u2010ones by a Combination of Fe(NO<sub>3<\/sub>)<sub>3<\/sub> and NaNO<sub>2<\/sub>: Discovery of a New Readily Available Class of Fungicides, 4\u2010Nitropyrazolin\u20105\u2010ones"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-7319","authenticated-orcid":false,"given":"Igor B.","family":"Krylov","sequence":"first","affiliation":[{"name":"N.\u2005D. 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