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Although several transition\u2010metal\u2010based systems have been developed for this transformation, the use of main\u2010group compounds remains less explored. In recent years, several strategies for C\u2212F bond activation have focused on the use of phosphorus\u2010based reagents. In this Minireview, an overview of strategies is provided that exploits P<jats:sup>V<\/jats:sup> and P<jats:sup>III<\/jats:sup>\u2010based Lewis acids as well as P<jats:sup>III<\/jats:sup> Lewis bases in frustrated Lewis pair (FLP) protocols for hydrodefluorination, C\u2212C couplings and C\u2212F derivatizations.<\/jats:p>","DOI":"10.1002\/chem.201900542","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T01:18:47Z","timestamp":1551143927000},"page":"9350-9357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["C\u2212F Bond Activation Mediated by Phosphorus Compounds"],"prefix":"10.1002","volume":"25","author":[{"given":"Julia M.","family":"Bayne","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St. George St. Toronto Ontario M5S 3H6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-8355","authenticated-orcid":false,"given":"Douglas W.","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St. George St. Toronto Ontario M5S 3H6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1021\/cr4002879","volume":"114","author":"Wang J.","year":"2014","journal-title":"Chem. 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