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Unique copper\u2010, copper\/iron\u2010 and iron\u2010modified graphene oxide nanocomposites have a submicron size that is smaller than that of pristine GO and a higher surface area enriched with Cu<jats:sub>2<\/jats:sub>O, CuO, and Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> of multiform phases (\u03b1\u2010, \u03b2\u2010, \u03f5\u2010, or \u03b3), FeO(OH), and sulfur\u2010 or carbon\u2010containing compounds. These nanocomposites are sonochemically intercalated with the nonsteroidal anti\u2010inflammatory drug ketorolac, which results in the formation of nanoscale carriers. Ketorolac monotonically disintegrates from these nanoscale carriers in aqueous solution upon adjustment of the pH from 1 to 8. 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