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It displayed a highly enantioselective fluorescence response toward structurally diverse amino acids in a biphasic fluorous\/aqueous system with enantiomeric fluorescent enhancement ratio (\n                    <jats:italic>ef<\/jats:italic>\n                    ; \u0394\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>D<\/jats:sub>\n                    \/\u0394\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>L<\/jats:sub>\n                    ) values up to 45.2 (histidine). It can be used to determine the enantiomeric compositions of amino acids and also allows the amino acid enantiomers to be visually discriminated. NMR and mass\u2010spectroscopic investigations provided insights into the observed high enantioselectivity. This biphasic fluorescent recognition was used to determine the enantiomeric composition of the crude phenylalanine products generated by an enzyme\u2010catalyzed asymmetric hydrolysis under various reaction conditions. The fluorous\u2010phase\u2010based fluorescence measurement under the biphasic conditions was able to minimize the interference of other reaction components and thus has potential in asymmetric reaction screening.\n                  <\/jats:p>","DOI":"10.1002\/chem.201900880","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T12:36:54Z","timestamp":1553085414000},"page":"7866-7873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Biphasic Enantioselective Fluorescent Recognition of Amino Acids by a Fluorophilic Probe"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-5048","authenticated-orcid":false,"given":"Yuan\u2010Yuan","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Chemistry and Environmental Engineering Wuhan Institute of Technology  Wuhan 430205 P.\u2005R. China"},{"name":"Department of Chemistry University of Virginia  Charlottesville Virginia 22904 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Virginia  Charlottesville Virginia 22904 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Abed","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Virginia  Charlottesville Virginia 22904 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0159-4616","authenticated-orcid":false,"given":"Shuang\u2010Xi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Virginia  Charlottesville Virginia 22904 USA"},{"name":"Key Laboratory for Green Chemical Process of Ministry of Education School of Chemical Engineering and Pharmacy Wuhan Institute of Technology  Wuhan 430205 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8698-3228","authenticated-orcid":false,"given":"Lin","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Virginia  Charlottesville Virginia 22904 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"Reviews on enantioselective fluorescent 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