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The observed electrophilic substitution at the 5,5\u2032\u2010positons of an optically active binaphthyl compound is unprecedented. Unlike unbrominated 3,3\u2032\u2010diformyl\u20101,1\u2032\u2010bi\u20102\u2010naphthol, which is not suitable for fluorescent recognition in water, compound (<jats:italic>S<\/jats:italic>)\u2010<jats:bold>2<\/jats:bold>, in combination with Zn<jats:sup>2+<\/jats:sup>, exhibits a highly enantioselective fluorescent response toward amino acids in aqueous solution (HEPES buffer, pH\u20057.4). It is further found that the condensation product of (<jats:italic>R<\/jats:italic>)\u2010<jats:bold>2<\/jats:bold> with tryptophan, (<jats:italic>R<\/jats:italic>)\u2010<jats:bold>3<\/jats:bold>, shows dual\u2010responsive emissions toward amino acids; the short wavelength (<jats:italic>\u03bb<\/jats:italic><jats:sub>1<\/jats:sub>=350\u2005nm) emission is sensitive to the concentration of the substrate regardless of the chiral configuration and the long wavelength (<jats:italic>\u03bb<\/jats:italic><jats:sub>2<\/jats:sub>&gt;500\u2005nm) emission is highly enantioselective. Thus, the use of (<jats:italic>R<\/jats:italic>)\u2010<jats:bold>3<\/jats:bold> allows the simultaneous determination of the concentration and enantiomeric composition of an amino acid sample from one fluorescence measurement.<\/jats:p>","DOI":"10.1002\/chem.201901374","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T12:55:37Z","timestamp":1557147337000},"page":"9967-9972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Simultaneous Determination of Concentration and Enantiomeric Composition of Amino Acids in Aqueous Solution by Using a Tetrabromobinaphthyl Dialdehyde Probe"],"prefix":"10.1002","volume":"25","author":[{"given":"Shahzad","family":"Iqbal","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry, Sichuan University  Chengdu 610064 P.R. 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