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In the enzyme peptidylglycine \u03b1\u2010hydroxylating monooxygenase (PHM), the hydroxylating activity towards aliphatic substrates arises from the cooperative effect between two copper atoms, but the detailed mechanism has yet to be fully clarified. Herein, we report on a model complex showing hydroxylation of an aliphatic ligand initiated by dioxygen. According to DFT calculations, the proton\u2010coupled electron\u2010transfer (PCET) process leading to ligand hydroxylation in this complex benefits from cooperative effects between the two copper atoms. While one copper atom is responsible for dioxygen binding and activation, the other stabilizes the product of intramolecular PCET by copper\u2013ligand charge transfer. The results of this work might pave the way for the directed utilization of cooperative effects in oxidation reactions.<\/jats:p>","DOI":"10.1002\/chem.201901906","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T05:54:19Z","timestamp":1558936459000},"page":"11257-11268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["On the Metal Cooperativity in a Dinuclear Copper\u2013Guanidine Complex for Aliphatic C\u2212H Bond Cleavage by Dioxygen"],"prefix":"10.1002","volume":"25","author":[{"given":"Florian","family":"Sch\u00f6n","sequence":"first","affiliation":[{"name":"Anorganisch-Chemisches Institut Ruprecht-Karls-Universit\u00e4t Heidelberg  Im Neuenheimer Feld 270 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Biebl","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Nanostruktur- und Festk\u00f6rperphysik 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