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The cleavage of the Hg\u2212C bond of MeHgCl at low temperature, therefore, is of significant importance for human health. Among various bis(imidazole)\u20102\u2010selones L<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub>Se (<jats:italic>n<\/jats:italic>=1\u20134, or 6), the three\u2010spacer L<jats:sub>3<\/jats:sub>Se shows extraordinarily high reactivity in the degradation of various mercury alkyls including MeHgCl because of its unique ability to coordinate through \u03ba<jats:sup>2<\/jats:sup>\u2010fashion, in which both the Se atoms simultaneously attack the Hg center of mercury alkyls for facile Hg\u2212C bond cleavage. It has the highest softness (\u03c3) parameter and the lowest HOMO(L<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub>Se)\u2010LUMO(MeHgX) energy gap and, thus, L<jats:sub>3<\/jats:sub>Se is the most reactive among L<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub>Se towards MeHgX (X=Cl or I). L<jats:sub>3<\/jats:sub>Se is highly efficient, more than L<jats:sub>1<\/jats:sub>Se, in restoring the activity of antioxidant enzyme glutathione reductase (GR) that is completely inhibited by MeHgCl; 80\u2009% GR activity is recovered by L<jats:sub>3<\/jats:sub>Se relative to 50\u2009% by L<jats:sub>1<\/jats:sub>Se. It shows an excellent cytoprotective effect in liver cells against MeHgCl\u2010induced oxidative stress by protecting vital antioxidant enzymes from inhibition caused by MeHgCl and, thus, does not allow to increase the intracellular reactive oxygen species (ROS) levels. Furthermore, it protects the mitochondrial membrane potential (\u0394<jats:italic>\u03a8<\/jats:italic><jats:sub>m<\/jats:sub>) from perturbation by MeHgCl. Major Hg\u2010responsive genes analyses demonstrate that L<jats:sub>3<\/jats:sub>Se plays a significant role in MeHg<jats:sup>+<\/jats:sup> detoxification in liver cells.<\/jats:p>","DOI":"10.1002\/chem.201902578","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T07:26:37Z","timestamp":1562916397000},"page":"12810-12819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploiting the \u03ba<sup>2<\/sup>\u2010Fashioned Coordination of [Se<sub>2<\/sub>]\u2010Donor Ligand L<sub>3<\/sub>Se for Facile Hg\u2212C Bond Cleavage of Mercury Alkyls and Cytoprotection against Methylmercury\u2010Induced Toxicity"],"prefix":"10.1002","volume":"25","author":[{"given":"Ramesh","family":"Karri","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Natural Sciences Shiv Nadar University, NH91  Greater Noida UP 201314 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Chalana","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Natural Sciences Shiv Nadar University, NH91  Greater Noida UP 201314 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binayak","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Natural Sciences Shiv Nadar University, NH91  Greater Noida UP 201314 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Krishna","family":"Jayadev","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Natural Sciences Shiv Nadar University, NH91  Greater Noida UP 201314 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-3575","authenticated-orcid":false,"given":"Gouriprasanna","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Natural Sciences Shiv Nadar University, NH91  Greater Noida UP 201314 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408440600845619"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408440701385770"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408369708998098"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/es305071v"},{"key":"e_1_2_7_6_1","unstructured":"\u00a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/es103384v"},{"key":"e_1_2_7_8_2","first-page":"631","volume-title":"Mercury Pollution: Integration and Synthesis","year":"1994"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10643389609388485"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9310031"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/es071948x"},{"key":"e_1_2_7_12_1","unstructured":"\u00a0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710133200"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.05.019"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.05.013"},{"key":"e_1_2_7_16_2","author":"Nogara P. 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