{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:25Z","timestamp":1786977325438,"version":"build-2736575974"},"reference-count":104,"publisher":"Wiley","issue":"54","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["398461692"],"award-info":[{"award-number":["398461692"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010134","name":"Evonik Stiftung","doi-asserted-by":"publisher","award":["n.a."],"award-info":[{"award-number":["n.a."]}],"id":[{"id":"10.13039\/100010134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005341","name":"Bayerisches Staatsministerium f\u00fcr Wissenschaft, Forschung und Kunst","doi-asserted-by":"publisher","award":["SolTech Consortium"],"award-info":[{"award-number":["SolTech Consortium"]}],"id":[{"id":"10.13039\/501100005341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug\u2010loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra\u2010high curcumin loading exceeding 50\u2005wt.%, while the other allows a drug loading of only 25\u2005wt.%. In the low capacity micelles, steady\u2010state fluorescence revealed a very unusual feature of curcumin fluorescence, a high energy emission at 510\u2005nm. Time\u2010resolved fluorescence upconversion showed that the fluorescence life time of the corresponding species is too short in the high\u2010capacity micelles, preventing an observable emission in steady\u2010state. Therefore, contrary to common perception, stronger interactions between host and guest can be detrimental to the drug loading in polymer micelles.<\/jats:p>","DOI":"10.1002\/chem.201902619","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T10:59:53Z","timestamp":1562756393000},"page":"12601-12610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Ultra\u2010High to Ultra\u2010Low Drug\u2010Loaded Micelles: Probing Host\u2013Guest Interactions by Fluorescence Spectroscopy"],"prefix":"10.1002","volume":"25","author":[{"given":"Michael M.","family":"L\u00fcbtow","sequence":"first","affiliation":[{"name":"Functional Polymer Materials, Chair for Advanced Materials Synthesis Department of Chemistry and Pharmacy and Bavarian Polymer Institute University of W\u00fcrzburg  R\u00f6ntgenring 11 97070 W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Center for Nanosystems Chemistry University of W\u00fcrzburg  Am Hubland 97070 W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schmiedel","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Center for Nanosystems Chemistry University of W\u00fcrzburg  Am Hubland 97070 W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Roos","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Center for Nanosystems Chemistry University of W\u00fcrzburg  Am Hubland 97070 W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-9165","authenticated-orcid":false,"given":"Christoph","family":"Lambert","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Center for Nanosystems Chemistry University of W\u00fcrzburg  Am Hubland 97070 W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-7404","authenticated-orcid":false,"given":"Robert","family":"Luxenhofer","sequence":"additional","affiliation":[{"name":"Functional Polymer Materials, Chair for Advanced Materials Synthesis Department of Chemistry and Pharmacy and Bavarian Polymer Institute University of W\u00fcrzburg  R\u00f6ntgenring 11 97070 W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80075"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107724"},{"key":"e_1_2_7_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201107724"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05648.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_16"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_8"},{"key":"e_1_2_7_8_1","first-page":"636053","author":"Zhang D.-w.","year":"2013","journal-title":"Evid.-Based Complementary Altern. Med."},{"key":"e_1_2_7_9_1","first-page":"141","volume":"14","author":"Jurenka J. S.","year":"2009","journal-title":"Altern. Med. Rev."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10322"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.8.1859"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.018"},{"key":"e_1_2_7_13_1","unstructured":"\u00a0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00655-3"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-147.v1"},{"key":"e_1_2_7_16_1","unstructured":"\u00a0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b00244"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.618785"},{"key":"e_1_2_7_19_1","unstructured":"\u00a0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.01.004"},{"key":"e_1_2_7_21_2","first-page":"501","volume":"24","author":"Lirdprapamongkol K.","year":"2010","journal-title":"In Vivo"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/513481a"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/543040c"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics4040517"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2007.064"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.07.008"},{"key":"e_1_2_7_28_1","unstructured":"\u00a0"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.090"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.916686"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00057"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12776"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03604"},{"key":"e_1_2_7_34_1","unstructured":"\u00a0"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810087"},{"key":"e_1_2_7_35_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201810087"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507281"},{"key":"e_1_2_7_36_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201507281"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm400234c"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.022"},{"key":"e_1_2_7_39_1","unstructured":"\u00a0"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.057"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn406388t"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.002"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05376"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.04.014"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201500465"},{"key":"e_1_2_7_46_1","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800155"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00708"},{"key":"e_1_2_7_49_1","unstructured":"\u00a0"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2003.07.013"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2016.1161248"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochemrev.2009.05.001"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2011.04.016"},{"key":"e_1_2_7_54_1","unstructured":"\u00a0"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/qua.20469"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00214-009-0604-2"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.11.048"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp411778q"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp507378w"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2010.08.002"},{"key":"e_1_2_7_61_1","unstructured":"\u00a0"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp9101527"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/la5023533"},{"key":"e_1_2_7_64_1","unstructured":"\u00a0"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01589a021"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00746a004"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1524\/zpch.1971.75.1_2.063"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/andp.18962940507"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/andp.19213701105"},{"key":"e_1_2_7_70_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1515\/zpch-1914-8603","volume":"86","author":"Stark J.","year":"1914","journal-title":"Z. Phys. Chem."},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802612802652466"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.05.096"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.06.011"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-1425(03)00342-1"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp1038249"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32808"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-015-2655-8"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp901234z"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4948932"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/la203592j"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(96)02024-9"},{"key":"e_1_2_7_82_1","first-page":"388","volume":"7","author":"Waranyoupalin R.","year":"2009","journal-title":"Cent. Eur. J. Chem."},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2000)0720625EOSOTE2.0.CO2"},{"key":"e_1_2_7_84_1","unstructured":"\u00a0"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2CP23144A"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1039\/b316149h"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra45095c"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp401840z"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805620"},{"key":"e_1_2_7_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201805620"},{"key":"e_1_2_7_90_1","unstructured":"\u00a0"},{"key":"e_1_2_7_91_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/928407"},{"key":"e_1_2_7_92_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2000)0720625EOSOTE2.0.CO2"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1998.tb09082.x"},{"key":"e_1_2_7_94_1","unstructured":"\u00a0"},{"key":"e_1_2_7_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.02.024"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b07878"},{"key":"e_1_2_7_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.10.032"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.3556"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00618"},{"key":"e_1_2_7_100_1","author":"Haider M. S.","year":"2019","journal-title":"ChemRxiv"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.201902619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201902619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.201902619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201902619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:57:15Z","timestamp":1760302635000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.201902619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":104,"journal-issue":{"issue":"54","published-print":{"date-parts":[[2019,9,25]]}},"alternative-id":["10.1002\/chem.201902619"],"URL":"https:\/\/doi.org\/10.1002\/chem.201902619","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.8241107.v1","asserted-by":"object"}]},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,2]]},"assertion":[{"value":"2019-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}