{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:05:44Z","timestamp":1787061944071,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"71","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BU2725\/5-1"],"award-info":[{"award-number":["BU2725\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BU2725\/8-1"],"award-info":[{"award-number":["BU2725\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The interplay of metal ions with polysaccharides is important for the immune recognition in the lung. Due to the localization of beryllium associated diseases to the lung, it is likely that beryllium carbohydrate complexes play a vital role for the development of berylliosis. Herein, we present a detailed study on the interaction of Be\n                    <jats:sup>2+<\/jats:sup>\n                    ions with fructose and glucose as well as simpler biomimetic ligands, which emulate binding motives of saccharides. Through NMR and IR spectroscopy as well as single\u2010crystal X\u2010ray diffraction, complemented by competition reactions we were able to determine a distinctive trend in the binding affinity of these ligands. This suggests that under physiological conditions beryllium ions are only bound irreversibly in glycoproteins or polysaccharides if a quasi ideal tetrahedral environment and \u03ba\n                    <jats:sup>4<\/jats:sup>\n                    \u2010coordination is provided by the respective biomolecule. Furthermore, Lewis acid induced conversions of the ligands and an extreme increase in the Br\u00f8nstedt acidity of the present OH\u2010groups imply that upon enclosure of Be\n                    <jats:sup>2+<\/jats:sup>\n                    , alterations may be induced by the metal ion in glycoproteins or polysaccharides. In addition the frequent formation of Be\u2010O\u2010heterocycles indicates that multinuclear beryllium compounds might be the actual trigger of berylliosis. This investigation on beryllium coordination chemistry was supplemented by binding studies of selected biomimetic ligands with Al\n                    <jats:sup>3+<\/jats:sup>\n                    , Zn\n                    <jats:sup>2+<\/jats:sup>\n                    , Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , and Li\n                    <jats:sup>+<\/jats:sup>\n                    , which revealed that none of these beryllium related ions was tetrahedrally coordinated under the give conditions. Therefore, studies on the metabolization of beryllium compounds cannot be performed with other hard cations as a substitute for the hazardous Be\n                    <jats:sup>2+<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/chem.201903439","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T10:28:51Z","timestamp":1568024931000},"page":"16257-16269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Understanding the Localization of Berylliosis: Interaction of Be\n                    <sup>2+<\/sup>\n                    with Carbohydrates and Related Biomimetic Ligands"],"prefix":"10.1002","volume":"25","author":[{"given":"Matthias","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Anorganische Chemie, Nachwuchsgruppe Berylliumchemie Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Stra\u00dfe 4 35032 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-6797","authenticated-orcid":false,"given":"Magnus R.","family":"Buchner","sequence":"additional","affiliation":[{"name":"Anorganische Chemie, Nachwuchsgruppe Berylliumchemie Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Stra\u00dfe 4 35032 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.341.6141.26"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06939"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-184556"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135299"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.06.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2306"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300392110"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8105535"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3874"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.048"},{"key":"e_1_2_11_11_1","first-page":"1137","volume":"24","author":"Dutra F. 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