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Most family members were identified almost four decades ago and were placed on the shelf due to the numbers of broad\u2010spectrum compounds available at the time. However, in light of rising rates of antimicrobial resistance, there has been a renewed interest in the use of narrow\u2010spectrum antimicrobials. Here, we review the history of this family of compounds, including synthetic approaches, and highlight the recently uncovered genetic basis for nargenicin production. Given the renewed pharmaceutical interest in these compounds, we also investigate structure\u2013activity relationships among these molecules, with a view to the future development of members of this unusual antibiotic family.<\/jats:p>","DOI":"10.1002\/chem.201904053","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T22:55:04Z","timestamp":1572476104000},"page":"2780-2792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Nargenicin Family of Oxa\u2010Bridged Macrolide Antibiotics"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-6614","authenticated-orcid":false,"given":"Sacha J.","family":"Pidot","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology at the Doherty Institute University of Melbourne  3000 Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-1303","authenticated-orcid":false,"given":"Mark A.","family":"Rizzacasa","sequence":"additional","affiliation":[{"name":"School of Chemistry The Bio21 Molecular Science and Biotechnology Institute University of Melbourne  3000 Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","volume":"1830","author":"Cragg G. 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