{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:09:26Z","timestamp":1761948566908,"version":"build-2065373602"},"reference-count":169,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2018\/001897, CRG\/2019\/000489, 3511410812018-BRNS\/35032"],"award-info":[{"award-number":["CRG\/2018\/001897, CRG\/2019\/000489, 3511410812018-BRNS\/35032"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Macrocyclic alkaloids (macrolides) and cyclopeptides have an immense range of applications in drug discovery research because of their natural abundance and potential biological and physicochemical properties. Presently, more than 100 approved drugs or clinical drug candidates contain macrocyclic scaffolds as the biologically active component. This review provides an interesting perspective about the use of amino acid\u2010derived chiral pools versus other methods derived from miscellaneous synthons towards the total synthesis of non\u2010peptidic macrolides. The synthetic routes and the key strategies involved in the total syntheses of ten natural macrolides have been discussed. Both the amino acid\u2010derived and non\u2010amino acid\u2010derived synthetic routes have been illustrated to present a comparative study between the two approaches.<\/jats:p>","DOI":"10.1002\/chem.201904564","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T10:22:08Z","timestamp":1576578128000},"page":"5131-5156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Comparative Synthetic Strategy Perspective on \u03b1\u2010Amino Acid\u2010 and Non\u2010Amino Acid\u2010Derived Synthons towards Total Syntheses of Selected Natural Macrolides"],"prefix":"10.1002","volume":"26","author":[{"given":"Srinivas Lavanya","family":"Kumar Manda","sequence":"first","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute  Sector-10, Jankipuram Extension Lucknow 226031 India"},{"name":"Chemical Sciences Division Academy of Scientific and Innovative Research (AcSIR)  New Delhi 110025 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute  Sector-10, Jankipuram Extension Lucknow 226031 India"},{"name":"Chemical Sciences Division Academy of Scientific and Innovative Research (AcSIR)  New Delhi 110025 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Ghoshal","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute  Sector-10, Jankipuram Extension Lucknow 226031 India"},{"name":"Chemical Sciences Division Academy of Scientific and Innovative Research (AcSIR)  New Delhi 110025 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayur D.","family":"Ambule","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute  Sector-10, Jankipuram Extension Lucknow 226031 India"},{"name":"Chemical Sciences Division Academy of Scientific and Innovative Research (AcSIR)  New Delhi 110025 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-7153","authenticated-orcid":false,"given":"Ajay Kumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute  Sector-10, Jankipuram Extension Lucknow 226031 India"},{"name":"Chemical Sciences Division Academy of Scientific and Innovative Research (AcSIR)  New Delhi 110025 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-4579","authenticated-orcid":false,"given":"Gautam","family":"Panda","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute  Sector-10, Jankipuram Extension Lucknow 226031 India"},{"name":"Chemical Sciences Division Academy of Scientific and Innovative Research (AcSIR)  New Delhi 110025 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503428"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200503428"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2590"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002809"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201002809"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201001715"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm1012374"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00063"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00838"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00742"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13178"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00084"},{"key":"e_1_2_8_12_1","unstructured":"\u00a0"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-005-1314-x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198205121"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19820940705"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/b96883"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300626"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200300626"},{"key":"e_1_2_8_17_1","unstructured":"\u00a0"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200352229"},{"key":"e_1_2_8_18_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200352229"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199720971"},{"key":"e_1_2_8_19_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19971091917"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja003976k"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja992658m"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol034077e"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol035773h"},{"key":"e_1_2_8_24_1","unstructured":"\u00a0"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(03)01378-9"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol061782p"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.200540214"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200500703"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-950335"},{"key":"e_1_2_8_30_1","unstructured":"\u00a0"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)01287-4"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1039\/b210952b"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/b414374d"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00744"},{"key":"e_1_2_8_35_1","first-page":"162","volume-title":"Progress in the Chemistry of Organic Natural Products, Vol.\u200528","author":"Warnhoff E. W.","year":"1970"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1876-0813(08)60276-6","volume-title":"The Alkaloids: Chemistry and Physiology","author":"Tschesche R.","year":"1975"},{"key":"e_1_2_8_37_1","unstructured":"\u00a0"},{"key":"e_1_2_8_38_2","first-page":"299","volume-title":"The Alkaloids: Chemistry and Pharmacology","author":"Schmidt U.","year":"1985"},{"key":"e_1_2_8_39_2","first-page":"113","volume-title":"Alkaloids:\u2009 Chemical and Biological Perspectives, Vol.\u20053","author":"Joullie M. M.","year":"1985"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/B400334A"},{"key":"e_1_2_8_41_1","first-page":"1","volume-title":"Progress in the Chemistry of Organic Natural Products, Vol.\u200575","author":"Gournelis D. C.","year":"1998"},{"key":"e_1_2_8_42_1","first-page":"388","volume":"32","author":"Tan N. H.","year":"1997","journal-title":"Acta Pharm. Sin."},{"key":"e_1_2_8_43_1","first-page":"301","volume-title":"The Alkaloids","author":"Itokawa H.","year":"1997"},{"key":"e_1_2_8_44_1","unstructured":"\u00a0"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2017.02.029"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB00943F"},{"key":"e_1_2_8_47_1","unstructured":"\u00a0"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201200732"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo302359h"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob27518c"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604764"},{"key":"e_1_2_8_51_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201604764"},{"key":"e_1_2_8_52_1","unstructured":"\u00a0"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1992-26176"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00042a010"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol100123p"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201108692"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201108692"},{"key":"e_1_2_8_57_1","unstructured":"\u00a0"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol302219x"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201108749"},{"key":"e_1_2_8_59_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201108749"},{"key":"e_1_2_8_60_1","unstructured":"\u00a0"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201200871"},{"key":"e_1_2_8_61_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201200871"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2013.227"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00193"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403176"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(96)01149-5"},{"key":"e_1_2_8_66_1","unstructured":"\u00a0"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja012220y"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja020635t"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol901167g"},{"key":"e_1_2_8_70_1","unstructured":"\u00a0"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol201626h"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201200286"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202553"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9MD00164F"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol900579k"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.130960"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00660"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00298"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00713"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.12.050"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00124a015"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja055967n"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol401357k"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17010058"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)74677-6"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00072-8"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo048854f"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b01519"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja710363p"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja017277z"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(95)00427-A"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol052287g"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.06.071"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.11.165"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00136a009"},{"key":"e_1_2_8_96_1","unstructured":"\u00a0"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol990830l"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol990829m"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0105055"},{"key":"e_1_2_8_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja011604l"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402477101"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/B308305E"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1994-25398"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1089099"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob25766a"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00573-6"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo701816h"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol9014317"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.12.043"},{"key":"e_1_2_8_110_1","unstructured":"\u00a0"},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)88394-X"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.37.110"},{"key":"e_1_2_8_113_1","unstructured":"\u00a0"},{"key":"e_1_2_8_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)02350-X"},{"key":"e_1_2_8_115_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo970314d"},{"key":"e_1_2_8_116_1","unstructured":"\u00a0"},{"key":"e_1_2_8_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1652::AID-ANIE1652>3.0.CO;2-K"},{"key":"e_1_2_8_117_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19990601)111:11<1760::AID-ANGE1760>3.0.CO;2-A"},{"key":"e_1_2_8_118_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo016413f"},{"key":"e_1_2_8_119_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja017885e"},{"key":"e_1_2_8_120_1","unstructured":"\u00a0"},{"key":"e_1_2_8_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201102797"},{"key":"e_1_2_8_122_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200804645"},{"key":"e_1_2_8_122_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200804645"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja011452u"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201403299"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.04.075"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.741"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201301978"},{"key":"e_1_2_8_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201301978"},{"key":"e_1_2_8_128_1","unstructured":"\u00a0"},{"key":"e_1_2_8_129_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201946"},{"key":"e_1_2_8_129_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201201946"},{"key":"e_1_2_8_130_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol203130b"},{"key":"e_1_2_8_131_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201302197"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol301103d"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006780"},{"key":"e_1_2_8_133_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201006780"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja010015c"},{"key":"e_1_2_8_135_1","unstructured":"\u00a0"},{"key":"e_1_2_8_136_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200500702"},{"key":"e_1_2_8_136_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200500702"},{"key":"e_1_2_8_137_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja060064v"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200461239"},{"key":"e_1_2_8_138_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200461239"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200600383"},{"key":"e_1_2_8_140_1","unstructured":"\u00a0"},{"key":"e_1_2_8_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.12.026"},{"key":"e_1_2_8_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.06.111"},{"key":"e_1_2_8_143_1","unstructured":"\u00a0"},{"key":"e_1_2_8_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)84305-1"},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00366a011"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.60.377"},{"key":"e_1_2_8_147_1","unstructured":"\u00a0"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1573"},{"key":"e_1_2_8_149_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1580"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39940001003"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo9718253"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.47.982"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.201904564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201904564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.201904564","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201904564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:35:47Z","timestamp":1760261747000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.201904564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":169,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,4,21]]}},"alternative-id":["10.1002\/chem.201904564"],"URL":"https:\/\/doi.org\/10.1002\/chem.201904564","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"type":"print","value":"0947-6539"},{"type":"electronic","value":"1521-3765"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}