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One strategy to overcome this is to make new derivatives of existing drugs by conjugation to organometallic fragments, either by an appropriate linker, or by direct coordination of the drug to a metal. We illustrate this with examples of conjugated organometallic metallocene sandwich and half\u2010sandwich complexes, Ru\n                    <jats:sup>II<\/jats:sup>\n                    and Os\n                    <jats:sup>II<\/jats:sup>\n                    arene, and Rh\n                    <jats:sup>III<\/jats:sup>\n                    and Ir\n                    <jats:sup>III<\/jats:sup>\n                    cyclopentadienyl half\u2010sandwich complexes. Ferrocene conjugates are particularly promising. The ferrocene\u2013chloroquine conjugate ferroquine is in clinical trials for malaria treatment, and a ferrocene\u2010tamoxifen derivative (a ferrocifen) seems likely to enter anticancer trails soon. Several other examples illustrate that organometallic conjugation can restore the activity of drugs to which resistance has developed.\n                  <\/jats:p>","DOI":"10.1002\/chem.201904699","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T05:41:35Z","timestamp":1590471695000},"page":"8676-8688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-7935","authenticated-orcid":false,"given":"Prinessa","family":"Chellan","sequence":"first","affiliation":[{"name":"Department of Chemistry and Polymer Science Stellenbosch University  7600 Matieland, Western Cape South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-1941","authenticated-orcid":false,"given":"Peter J.","family":"Sadler","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Warwick  Coventry CV4 7AL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2014.0182"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41143e"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201600908"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/om100964h"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.181"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/om300296n"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00166"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800504"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2012.05.028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-2976-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2005.04.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4291"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/b312109g"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.308"},{"key":"e_1_2_9_15_1","unstructured":"https:\/\/www.drugs.com\/pro\/trisenox.html. 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