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Herein, an efficient Lewis acid ZnCl<jats:sub>2<\/jats:sub> catalyzed [4+1] annulation of alkylthio\u2010substituted enaminones is reported, that is, \u03b1\u2010oxo ketene N,S\u2010acetals with sulfur ylides to afford 2\u2010acyl\u20103\u2010aminofuran derivatives. In a similar fashion, [4+1] annulation of the corresponding enaminothiones, that is, \u03b1\u2010thioxo ketene N,S\u2010acetals, with sulfur ylides efficiently proceeded to give multisubstituted 3\u2010aminothiophenes. This method features wide substrate scopes as well as broad functional group tolerance, offering a concise route to highly functionalized furans and thiophenes.<\/jats:p>","DOI":"10.1002\/chem.201905483","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T07:12:57Z","timestamp":1579072377000},"page":"4941-4946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["ZnCl<sub>2<\/sub>\u2010Catalyzed [4+1] Annulation of Alkylthio\u2010Substituted Enaminones and Enaminothiones with Sulfur Ylides"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-8433","authenticated-orcid":false,"given":"Yuan","family":"He","sequence":"first","affiliation":[{"name":"Dalian Institute of Chemical Physics Chinese Academy of Sciences  457 Zhongshan Road Dalian 116023 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. 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