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The high modularity of this approach has provided a library of COS\u2010based H\n                    <jats:sub>2<\/jats:sub>\n                    S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS\/H\n                    <jats:sub>2<\/jats:sub>\n                    S donor motifs, and that these groups release two equivalents of COS\/H\n                    <jats:sub>2<\/jats:sub>\n                    S and uncage an amine payload under physiologically relevant conditions. Additionally, we demonstrate that COS\/H\n                    <jats:sub>2<\/jats:sub>\n                    S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies.\n                  <\/jats:p>","DOI":"10.1002\/chem.201905577","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T02:30:35Z","timestamp":1579228235000},"page":"5374-5380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of Dithiasuccinoyl\u2010Caged Amines Enables COS\/H\n                    <sub>2<\/sub>\n                    S Release Lacking Electrophilic Byproducts"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-6169","authenticated-orcid":false,"given":"Matthew M.","family":"Cerda","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Materials Science Institute Knight Campus for Accelerating Scientific Impact Institute of Molecular Biology University of Oregon  Eugene Oregon 97403 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-1982","authenticated-orcid":false,"given":"Jenna L.","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Materials Science Institute Knight Campus for Accelerating Scientific Impact Institute of Molecular Biology University of Oregon  Eugene Oregon 97403 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma J.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Materials Science Institute Knight Campus for Accelerating Scientific Impact Institute of Molecular Biology University of Oregon  Eugene Oregon 97403 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-768X","authenticated-orcid":false,"given":"Christopher 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