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The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5\u2010HT2A<\/jats:sub> receptor antibody. In the presence of 25I\u2010NBOMe the capping antibody is displaced, leading to pore opening and rhodamine\u2005B release. This delivery was ascribed to 5\u2010HT2A<\/jats:sub> receptor antibody detachment from the surface due to its stronger coordination with 25I\u2010NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6\u2005\u03bcm<\/jats:sc>) and selective recognition of the 25I\u2010NBOMe drug (cocaine, heroin, mescaline, lysergic acid diethylamide, MDMA, and morphine were unable to induce pore opening and rhodamine\u2005B release). This nanodevice acts as a highly sensitive and selective fluorometric probe for the 25I\u2010NBOMe illicit drug in artificial saliva and in sweets.<\/jats:p>","DOI":"10.1002\/chem.201905688","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T06:02:08Z","timestamp":1578981728000},"page":"2813-2816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I\u2010NBOMe"],"prefix":"10.1002","volume":"26","author":[{"given":"Eva","family":"Garrido","sequence":"first","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Camino de Vera s\/n 46022 Valencia Spain"},{"name":"CIBER de Bioingenier\u00eda Biomaterialesy<\/i>Nanomedicina (CIBER-BBN) Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en 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