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Commonly synthetic methods for construction of the benzodiazepine ring derivatives are based on the condensation reactions of two highly functionalized synthons. The development of synthesis for these compounds, however, is hampered by the regioselectivity and atom economy. In this work, a one\u2010step synthesis of pyrido\u2010benzodiazepine backbones and its analogues is achieved through continuous ring\u2010opening hydrolysis of benzimidazole salts and intramolecular C\u2212H bond activation. 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