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It has been previously shown that salinomycin and its C20\u2010propargylamine derivative (Ironomycin (<jats:bold>2<\/jats:bold>)) accumulate in lysosomes and sequester iron in this organelle. Herein, a library of salinomycin derivatives is reported, including products of C20\u2010amination, C1\u2010esterification, C9\u2010oxidation, and C28\u2010dehydration. The biological activity of these compounds is evaluated against transformed human mammary epithelial HMLER CD24<jats:sup>low<\/jats:sup>\/CD44<jats:sup>high<\/jats:sup> cells, a well\u2010established model of breast CSC, and HMLER CD24<jats:sup>high<\/jats:sup>\/CD44<jats:sup>low<\/jats:sup> cells deprived of CSC properties. Unlike other structural alterations, derivative <jats:bold>4<\/jats:bold>, which displays a cyclopropylamine at position C20, showed a strikingly low IC<jats:sub>50<\/jats:sub> value of 23\u2005n<jats:sc>m<\/jats:sc> against HMLER CD24<jats:sup>low<\/jats:sup>\/CD44<jats:sup>high<\/jats:sup> cells. This study provides highly selective molecules to target the CSC niche, a potential interesting advance for drug development to prevent cancer resistance.<\/jats:p>","DOI":"10.1002\/chem.202000335","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T10:53:40Z","timestamp":1582282420000},"page":"7416-7424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Salinomycin Derivatives Kill Breast Cancer Stem Cells by Lysosomal Iron Targeting"],"prefix":"10.1002","volume":"26","author":[{"given":"Antoine","family":"Versini","sequence":"first","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-2603","authenticated-orcid":false,"given":"Ludovic","family":"Colombeau","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Hienzsch","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"},{"name":"Present address: ABX Advanced Biochemical Compounds  Heinrich-Glaeser-Str. 10\u201314 01454 Radeberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Gaillet","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Retailleau","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301 Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay  1 av. de la Terrasse 91198 Gif-sur-Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Debieu","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-5364","authenticated-orcid":false,"given":"Sebastian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Ca\u00f1eque","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-446X","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Institut Curie  26 rue d'Ulm 75248 Paris Cedex 05 France"},{"name":"PSL Universit\u00e9  60 rue Mazarine 75006 Paris France"},{"name":"Chemical Biology of Cancer Laboratory CNRS UMR 3666, INSERM U1143  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.53"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026043451500"},{"key":"e_1_2_7_6_2","first-page":"1","volume-title":"Wiley Encyclopedia of Chemical Biology","author":"Kingston D. 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