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The complexes were evaluated for antibacterial activity towards several problematic Gram\u2010positive (<jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>methicillin\u2010resistant Staphylococcus aureus<\/jats:italic> (MRSA), and <jats:italic>vancomycin\u2010resistant Enterococcus<\/jats:italic> (VRE)) and Gram\u2010negative (<jats:italic>Escherichia coli, Pseudomonas aeruginosa<\/jats:italic>) bacteria. The cell viability of COS\u20107 (monkey kidney) cells treated with the bismuth flavonolates was also studied to determine the effect of the complexes on mammalian cells. The heteroleptic complexes [BiPh(L)<jats:sub>2<\/jats:sub>] (in which L=flavonolate) showed good antibacterial activity towards all of the bacteria but reduced COS\u20107 cell viability in a concentration\u2010dependent manner. The homoleptic complexes [Bi(L)<jats:sub>3<\/jats:sub>] exhibited activity towards the Gram\u2010positive bacteria and showed low toxicity towards the mammalian cell line. Bismuth uptake studies in VRE and COS\u20107 cells treated with the bismuth flavonolate complexes indicated that Bi accumulation is influenced by both the substitution of the flavonolate ligands and the degree of substitution at the bismuth centre.<\/jats:p>","DOI":"10.1002\/chem.202000562","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T01:07:45Z","timestamp":1586999265000},"page":"7657-7671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bismuth(III) Flavonolates: The Impact of Structural Diversity on Antibacterial Activity, Mammalian Cell Viability and Cellular Uptake"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-8187","authenticated-orcid":false,"given":"Kirralee J.","family":"Burke","sequence":"first","affiliation":[{"name":"School of Chemistry Monash University  Clayton, Melbourne VIC 3800 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