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We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic \u03b3\u2010aminobutyric acid receptors (GABA\n                    <jats:sub>A<\/jats:sub>\n                    Rs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high\u2010resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition.\n                  <\/jats:p>","DOI":"10.1002\/chem.202000710","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T21:50:40Z","timestamp":1587333040000},"page":"12722-12727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Optical Control of GABA\n                    <sub>A<\/sub>\n                    Receptors with a Fulgimide\u2010Based Potentiator"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-1333","authenticated-orcid":false,"given":"Karin","family":"Rustler","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry Department of Chemistry and Pharmacy University of Regensburg  93053 Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-1521","authenticated-orcid":false,"given":"Galyna","family":"Maleeva","sequence":"additional","affiliation":[{"name":"INSERM, INS Institut de Neurosciences des Syst\u00e8mes Aix-Marseille University  13005 Marseille France"},{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-6171","authenticated-orcid":false,"given":"Alexandre M. J.","family":"Gomila","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-5577","authenticated-orcid":false,"given":"Pau","family":"Gorostiza","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Barcelona 08028 Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA)  08020 Barcelona Spain"},{"name":"Network Biomedical Research Center in Biomaterials Bioengineering and Nanomedicine (CIBER-bbn)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-7825","authenticated-orcid":false,"given":"Piotr","family":"Bregestovski","sequence":"additional","affiliation":[{"name":"INSERM, INS Institut de Neurosciences des Syst\u00e8mes Aix-Marseille University  13005 Marseille France"},{"name":"M. Sechenov First Moscow State Medical University  Moscow Russia"},{"name":"Institute of Neurosciences Kazan State Medical University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-4850","authenticated-orcid":false,"given":"Burkhard","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Department of Chemistry and Pharmacy University of Regensburg  93053 Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-101910-144233"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa7484"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249375"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22596"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902383116"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300179f"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja413063e"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00037"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00129"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00160"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB01101B"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2094"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14689"},{"key":"e_1_2_2_15_1","first-page":"744391","author":"Gomila A. 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