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Before pre\u2010clinical development, oral insulin products have first to be optimized in terms of encapsulation efficiency, protection against proteolysis, and intestinal permeation ability. With the use of dendritic mesoporous silica nanoparticles (DMSNs) as an insulin host and together with a protein\u2010based excipient, succinylated \u03b2\u2010lactoglobulin (BL), pH\u2010responsive tablets permitted the shielding of insulin from early release\/degradation in the stomach and mediated insulin permeation across the intestinal cellular membrane. 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