{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:11:07Z","timestamp":1789477867101,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51675296, 21868011"],"award-info":[{"award-number":["51675296, 21868011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2020,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis is a typical degenerative joint disease related to a lubrication deficiency of articular cartilage, which is characterized by increased friction at the joint surface and severe inflammation of the joint capsule. Consequently, therapies combining lubrication restoration and drug intervention are regarded as a promising strategy for the treatment of osteoarthritis. In the present study, thermo\u2010sensitive dual\u2010functional nanospheres, poly[<jats:italic>N<\/jats:italic>\u2010isopropylacrylamide\u20102\u2010methacryloyloxyethyl phosphorylcholine] (PNIPAM\u2010PMPC), are developed through emulsion polymerization. The PNIPAM\u2010PMPC nanospheres could enhance lubrication based on the hydration lubrication mechanism by forming a tenacious hydration layer surrounding the zwitterionic headgroups, and achieve local drug delivery by encapsulating the anti\u2010inflammatory drug diclofenac sodium. The lubrication and drug release tests showed improved lubrication and thermo\u2010sensitive drug release of the nanospheres. The in vitro test using cytokines\u2010treated chondrocytes indicated that the PNIPAM\u2010PMPC nanospheres were biocompatible and upregulated anabolic genes and simultaneously downregulated catabolic genes of the articular cartilage. In summary, the developed PNIPAM\u2010PMPC nanospheres, with the property of enhanced lubrication and local drug delivery, can be an effective nanomedicine for the treatment of osteoarthritis.<\/jats:p>","DOI":"10.1002\/chem.202001372","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T17:40:56Z","timestamp":1589910056000},"page":"10564-10574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Thermo\u2010Sensitive Dual\u2010Functional Nanospheres with Enhanced Lubrication and Drug Delivery for the Treatment of Osteoarthritis"],"prefix":"10.1002","volume":"26","author":[{"given":"Kuan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 P.R. China"},{"name":"School of Chemical and Biological Engineering Shandong University of, Science and Technology  Qingdao 266590 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielai","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing Research Institute of Automation for, Machinery Industry Co., Ltd  Beijing 100120 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Shandong University of, Science and Technology  Qingdao 266590 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-1455","authenticated-orcid":false,"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219289110"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166753"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.07.037"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym10050513"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC10069A"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.114"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00964"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.11.021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40544-013-0001-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-081514-123305"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169399"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.083"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1233"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja400695h"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900389"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.10.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201807559"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00201D"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201400201"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/b715522k"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201501101"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201702368"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804947"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800220"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500323"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b00405"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201900180"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b00338"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/am506026e"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp065041h"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07847"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b06236"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7497"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm3019664"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/b923969c"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b02441"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201400695"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.202001372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202001372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202001372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202001372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:12:18Z","timestamp":1760267538000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202001372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":40,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2020,8,17]]}},"alternative-id":["10.1002\/chem.202001372"],"URL":"https:\/\/doi.org\/10.1002\/chem.202001372","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]},"assertion":[{"value":"2020-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}