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As such, all of these aspects represent valid targets to counteract neurodegeneration and, therefore, the development of metal\u2010binding compounds with other properties to combat multifactorial disorders is definitely on the rise. Herein, the synthesis and in\u2010depth analysis of the first hybrids of carnosine and 8\u2010hydroxyquinoline, carnoquinolines (CarHQs), which combine the properties of the dipeptide with those of 8\u2010hydroxyquinoline, are reported. CarHQs and their copper complexes were characterized through several techniques, such as ESI\u2010MS and NMR, UV\/Vis, and circular dichroism spectroscopy. CarHQs can modulate self\u2010 and copper\u2010induced amyloid\u2010\u03b2 aggregation. These hybrids combine the antioxidant activity of their parent compounds. Therefore, they can simultaneously scavenge free radicals and reactive carbonyl species, thanks to the phenolic group and imidazole ring. These results indicate that CarHQs are promising multifunctional candidates for neurodegenerative disorders and they are worthy of further studies.<\/jats:p>","DOI":"10.1002\/chem.202001591","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T05:10:25Z","timestamp":1594012225000},"page":"16690-16705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein\u2013Protein Interactions, and Oxidative Stress"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-5949","authenticated-orcid":false,"given":"Francesco","family":"Bellia","sequence":"first","affiliation":[{"name":"Istituto di Cristallografia Consiglio Nazionale delle Ricerche  P. 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