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Hybridization of two chemically diverse compounds into a new bioactive effector product is a successful concept to improve the properties of a hybrid drug relative to the parent compounds. In this study, (iso)quinoline\u2013artemisinin hybrids, obtained through copper\u2010catalyzed azide\u2013alkyne cycloaddition or metal\u2010free click reactions (in organic solvents or in the presence of water), were analyzed\n                    <jats:italic>in vitro<\/jats:italic>\n                    , for the first time, for their inhibitory activity against human cytomegalovirus (HCMV), relative to their parent compounds and the reference drug ganciclovir. EC\n                    <jats:sub>50<\/jats:sub>\n                    (HCMV) values were obtained in a range 0.22\u20131.20\u2005\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    , which indicated highly potent antiviral properties in the absence of cytotoxic effects on normal cells (CC\n                    <jats:sub>50<\/jats:sub>\n                    &gt;100\u2005\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ). The most active hybrid,\n                    <jats:bold>1<\/jats:bold>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    =0.22\u2005\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ), is 25 times more potent than its parent compound artesunic acid (EC\n                    <jats:sub>50<\/jats:sub>\n                    =5.41\u2005\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ) and 12 times more efficient than the standard drug ganciclovir (EC\n                    <jats:sub>50<\/jats:sub>\n                    =2.6\u2005\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ). Interestingly, hybrid\n                    <jats:bold>1<\/jats:bold>\n                    also shows inhibitory activity against hepatitis\u2005B virus\n                    <jats:italic>in vitro<\/jats:italic>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    (HBeAg)=2.57\u2005\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/chem.202001803","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T13:42:50Z","timestamp":1591105370000},"page":"12019-12026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["(Iso)Quinoline\u2013Artemisinin Hybrids Prepared through Click Chemistry: Highly Potent Agents against Viruses"],"prefix":"10.1002","volume":"26","author":[{"given":"Aysun","family":"\u00c7apc\u0131","sequence":"first","affiliation":[{"name":"Organic Chemistry Chair I and Interdisciplinary Center for, Molecular Materials (ICMM) Friedrich-Alexander University of, Erlangen\u2013N\u00fcrnberg  Nikolaus Fiebiger-Stra\u00dfe 10 91058 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie M.","family":"Lorion","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mai","sequence":"additional","affiliation":[{"name":"Organic Chemistry Chair I and Interdisciplinary Center for, Molecular Materials (ICMM) Friedrich-Alexander University of, Erlangen\u2013N\u00fcrnberg  Nikolaus Fiebiger-Stra\u00dfe 10 91058 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Hahn","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Molecular Virology Friedrich-Alexander University of Erlangen-N\u00fcrnberg  Schlossgarten 4 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hodek","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry of the, Czech Academy of Sciences  Flemingovo namesti 2 16610 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Wangen","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Molecular Virology Friedrich-Alexander University of Erlangen-N\u00fcrnberg  Schlossgarten 4 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry of the, Czech Academy of Sciences  Flemingovo namesti 2 16610 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Marschall","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Molecular Virology Friedrich-Alexander University of Erlangen-N\u00fcrnberg  Schlossgarten 4 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK)  Potsdamer Str. 58 10785 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-0951","authenticated-orcid":false,"given":"Svetlana B.","family":"Tsogoeva","sequence":"additional","affiliation":[{"name":"Organic Chemistry Chair I and Interdisciplinary Center for, Molecular Materials (ICMM) 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