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There is a striking lack of attention to the threat of drug\u2010resistant fungal infections, with only a handful of new drugs currently in development. Given that metal complexes have proven to be useful new chemotypes in the fight against diseases such as cancer, malaria, and bacterial infections, it is reasonable to explore their possible utility in treating fungal infections. Herein we report a series of cobalt(III) Schiff base complexes with broad\u2010spectrum antifungal activity. Some of these complexes show minimum inhibitory concentrations (MIC) in the low micro\u2010 to nanomolar range against a series of\n                    <jats:italic>Candida<\/jats:italic>\n                    and\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    yeasts. Additionally, we demonstrate that these compounds show no cytotoxicity against both bacterial and human cells. Finally, we report the first in\u2005vivo toxicity data on these compounds in\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    , showing that doses as high as 266\u2005mg\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    are tolerated without adverse effects, paving the way for further in\u2005vivo studies of these complexes.\n                  <\/jats:p>","DOI":"10.1002\/chem.202003545","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T23:56:54Z","timestamp":1606262214000},"page":"2021-2029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Nontoxic Cobalt(III) Schiff Base Complexes with Broad\u2010Spectrum Antifungal Activity"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-2491","authenticated-orcid":false,"given":"Angelo","family":"Frei","sequence":"first","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Paden","family":"King","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-6572","authenticated-orcid":false,"given":"Amy K.","family":"Cain","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0025-4858","authenticated-orcid":false,"given":"Francesca L.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-3394","authenticated-orcid":false,"given":"Hue","family":"Dinh","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences Macquarie University  Sydney NSW 2109 Australia"},{"name":"Department of Biological Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-0484","authenticated-orcid":false,"given":"Alysha G.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-6020","authenticated-orcid":false,"given":"Johannes","family":"Zuegg","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-7982","authenticated-orcid":false,"given":"Justin J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-2292","authenticated-orcid":false,"given":"Mark A. T.","family":"Blaskovich","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.46"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30243-8"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1750368"},{"key":"e_1_2_7_6_2","unstructured":"CDC Fact Sheet 2018 https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-drug-resistant.html accessed 30.06.2020."},{"key":"e_1_2_7_7_1","unstructured":"\u00a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S119488"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0dt00292e"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00597"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00271"},{"key":"e_1_2_7_12_1","unstructured":"\u00a0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00211"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400460s"},{"key":"e_1_2_7_15_2","unstructured":"Bold Therapeutics2020 https:\/\/www.bold-therapeutics.com\/technology accessed 12.06.2020."},{"key":"e_1_2_7_16_1","unstructured":"\u00a0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0911-9"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2011183207"},{"key":"e_1_2_7_19_1","unstructured":"CMD2019 https:\/\/colmeddev.com\/trials\/ accessed 12.06.2020."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020090"},{"key":"e_1_2_7_21_1","unstructured":"Clinical Trials2020 https:\/\/clinicaltrials.gov accessed 12.06.2020."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT04231C"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","unstructured":"R. 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