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Herein, the approaches that have been applied to this bioactive natural product to date are reviewed. These synthetic endeavors have established the absolute stereochemistry of this molecule and allowed further investigation into its promising caspase\u2010independent bioactivity, while also contributing to the wider field of macrolide synthesis.<\/jats:p>","DOI":"10.1002\/chem.202003898","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T22:12:26Z","timestamp":1601331146000},"page":"2589-2611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Synthesis and Bioactivity of the Marine Macrolide Callyspongiolide"],"prefix":"10.1002","volume":"27","author":[{"given":"Kwang\u2010Yoon","family":"Ko","sequence":"first","affiliation":[{"name":"School of Chemical Sciences University of Auckland  23 Symonds Street Auckland 1142 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-9831","authenticated-orcid":false,"given":"Zoe E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences University of Auckland  23 Symonds Street Auckland 1142 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-4096","authenticated-orcid":false,"given":"Margaret A.","family":"Brimble","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences University of Auckland  23 Symonds Street Auckland 1142 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911897107"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12084539"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol403241v"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.11646\/zootaxa.4466.1.9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)00482-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960516p"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1545721"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50103a017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-06-10823"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0491787"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1155577"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.06.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00199-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps324151"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030006c"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15020871"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00074a017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(96)00125-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo060295k"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)00016-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/np000537q"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00485a059"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00011a006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17040241"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000534"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03533"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.80.1173"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/b607035c"},{"key":"e_1_2_7_29_1","unstructured":"T.Ye Z.Xu J.Zhou B.Gao CN105777702B 2016."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB01007E"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00370a050"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b01523"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB02051H"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja057686l"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)86584-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)97066-7"},{"key":"e_1_2_7_37_1","unstructured":"A. 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