{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:08:41Z","timestamp":1788908921728,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"66","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2020,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti\u2010infective effects have been confirmed. Herein, we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two relevant drug targets of severe acute respiratory syndrome coronaviruses (SARS\u2010CoV). The gold metallodrugs were effective inhibitors of the interaction of the SARS\u2010CoV\u20102 spike protein with the angiotensin converting enzyme 2 (ACE2) host receptor and might thus interfere with the viral entry process. The gold metallodrugs were also efficient inhibitors of the papain\u2010like protease (PLpro) of SARS\u2010CoV\u20101 and SARS\u2010CoV\u20102, which is a key enzyme in the viral replication. Regarding PLpro from SARS\u2010CoV\u20102, the here reported inhibitors are among the very first experimentally confirmed examples with activity against this target enzyme. Importantly, the activity of the complexes against both PLpro enzymes correlated with the ability of the inhibitors to remove zinc ions from the labile zinc center of the enzyme. Taken together, the results of this pilot study suggest further evaluation of gold complexes as SARS\u2010CoV antiviral drugs.<\/jats:p>","DOI":"10.1002\/chem.202004112","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T11:03:21Z","timestamp":1600945401000},"page":"15140-15144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike\u2010ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics**"],"prefix":"10.1002","volume":"26","author":[{"given":"Maria","family":"Gil\u2010Moles","sequence":"first","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttara","family":"Basu","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"B\u00fcssing","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"T\u00fcrck","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Varchmin","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-4618","authenticated-orcid":false,"given":"Ingo","family":"Ott","sequence":"additional","affiliation":[{"name":"Institute of Medicinal and Pharmaceutical Chemistry Technische Universit\u00e4t Braunschweig  Beethovenstrasse 55 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000223"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2762"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15562-9"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb3405"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.37"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40292"},{"key":"e_1_2_2_12_1","unstructured":"\u00a0"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104859"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000047"},{"key":"e_1_2_2_15_1","unstructured":"\u00a0"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.2.143"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300773"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1079"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-010-9293-5"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100801e"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201220n"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0716-8"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.12.020"},{"key":"e_1_2_2_24_1","unstructured":"\u00a0"},{"key":"e_1_2_2_25_2","first-page":"199","volume-title":"Metallo-drugs: Development and action of anticancer agents (De Gruyter)","author":"Casini A."},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00570B"},{"key":"e_1_2_2_27_2","volume-title":"Advances in Organometallic Chemistry","author":"Cerrada E."},{"key":"e_1_2_2_28_1","author":"Rut W.","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00093"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MT00262B"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC02646H"},{"key":"e_1_2_2_32_1","unstructured":"\u00a0"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2020.05.002"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00190"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/om300444c"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200801186"},{"key":"e_1_2_2_37_1","unstructured":"\u00a0"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900611t"},{"key":"e_1_2_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805240105"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202004112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202004112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202004112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:03:22Z","timestamp":1760288602000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202004112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":39,"journal-issue":{"issue":"66","published-print":{"date-parts":[[2020,11,26]]}},"alternative-id":["10.1002\/chem.202004112"],"URL":"https:\/\/doi.org\/10.1002\/chem.202004112","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.12488390.v1","asserted-by":"object"},{"id-type":"doi","id":"10.26434\/chemrxiv.12488390","asserted-by":"object"}]},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"2020-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}