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Detailed DFT calculations and NMR investigations support the experimental results. The described methodology was proven to be amenable to scale\u2010up and recyclability protocols. Contrasting classical procedures carried out under inert atmospheres, this work lays the foundation for a profound paradigm shift of the reactivity of carboxylic acid amides with organolithiums, with ketones being straightforwardly obtained by simply combining the reagents under aerobic conditions and with no need of using previously modified or pre\u2010activated amides, as recommended.<\/jats:p>","DOI":"10.1002\/chem.202004840","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T07:48:52Z","timestamp":1604562532000},"page":"2868-2874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A Fast and General Route to Ketones from Amides and Organolithium Compounds under Aerobic Conditions: Synthetic and Mechanistic Aspects"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4923-9130","authenticated-orcid":false,"given":"Simone","family":"Ghinato","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Torino  via P. 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