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These issues have been addressed by an innovative capsule design, in which nanocapsules are assembled on the microcapsule surface by electrostatic forces to form a pH\u2010responsive hierarchical capsule@capsule system. Here, melamine\u2010formaldehyde (MF) microcapsules with a negative surface charge were synthesized and coated with a novel MF\u2010polyethyleneimine (PEI) copolymer to achieve a positive charge of <jats:italic>\u03b6<\/jats:italic>=+28\u2005mV. This novel coating procedure allows the electrostatic assembly of negatively charged poly\u2010<jats:sc>l<\/jats:sc>\u2010lactide (PLLA, <jats:italic>\u03b6<\/jats:italic>=\u221219\u2005mV) and poly\u2010(lactide\u2010co\u2010glycolide) (PLGA, <jats:italic>\u03b6<\/jats:italic>=\u221256\u2005mV) nanocapsules on the microcapsule surface. Assembly studies at pH\u20057 gave a partial surface coverage of PLLA nanocapsules and full surface coverage for PLGA nanocapsules. The pH\u2010responsive adsorption and desorption of nanocapsules was shown at pH\u20057 and pH\u20053.<\/jats:p>","DOI":"10.1002\/chem.202100183","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T08:44:57Z","timestamp":1618217097000},"page":"9336-9341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Formulation of Next\u2010Generation Multicompartment Microcapsules by Reversible Electrostatic Attraction"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1364-9947","authenticated-orcid":false,"given":"Christian","family":"Neumann","sequence":"first","affiliation":[{"name":"Microencapsulation\/Polysaccharides Fraunhofer IAP  Geiselbergstr. 69 14476 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Bacher","sequence":"additional","affiliation":[{"name":"Nanoparticle Technology Fraunhofer IMM  Carl-Zeiss-Str.18-20 55129 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Musyanovych","sequence":"additional","affiliation":[{"name":"Nanoparticle Technology Fraunhofer IMM  Carl-Zeiss-Str.18-20 55129 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Tutus","sequence":"additional","affiliation":[{"name":"Membranes and functional films Fraunhofer IAP  Geiselbergstr. 69 14476 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Latnikova","sequence":"additional","affiliation":[{"name":"Microencapsulation\/Polysaccharides Fraunhofer IAP  Geiselbergstr. 69 14476 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.3144\/expresspolymlett.2020.35"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b09110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0CC04820H"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201913872"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201913872"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00632A"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2PY20636F"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2019.100033"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201600383"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201600383"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200900359"},{"key":"e_1_2_6_10_1","unstructured":"C. Neumann A. Latnikova M. Jobmann S. Rosencrantz Patent pending 10 2020 114 289.7."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12179"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1134\/S156009041806012X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142539"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3144\/expresspolymlett.2012.88"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cote.12379"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SM01634A"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA05533E"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-015-2888-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/gps-2016-0017"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2015.04.033"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717540600640302"},{"key":"e_1_2_6_22_1","first-page":"1","volume":"8","author":"Manavitehrani I.","year":"2016","journal-title":"Polymer"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202100183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202100183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202100183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:29:07Z","timestamp":1760275747000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202100183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":24,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2021,6,25]]}},"alternative-id":["10.1002\/chem.202100183"],"URL":"https:\/\/doi.org\/10.1002\/chem.202100183","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]},"assertion":[{"value":"2021-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}