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The dinuclear zinc complex catalyzed the reaction of a broad range of \u03b2,\u03b3\u2010unsaturated ketones to proceed at the \u03b1\u2010site exclusively, leading to corresponding adducts with two consecutive tertiary carbon stereocenters in diastereomeric ratios of up to &gt;20:1 and enantioselectivities generally in the 90\u201399\u2009% <jats:italic>ee<\/jats:italic> range. These products were used as general intermediates in the synthesis of multisubstituted cyclocanalines, tetrahydro pyridazinones, and 4<jats:italic>H<\/jats:italic>\u2010furo[2,3\u2010<jats:italic>b<\/jats:italic>][1,4]benzoxazine derivatives.<\/jats:p>","DOI":"10.1002\/chem.202100284","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T22:49:01Z","timestamp":1611614941000},"page":"5130-5135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Direct Asymmetric \u03b1\u2010Selective Mannich Reaction of \u03b2,\u03b3\u2010Unsaturated Ketones with Cyclic \u03b1\u2010Imino Ester: Divergent Synthesis of Cyclocanaline and Tetrahydro Pyridazinone Derivatives"],"prefix":"10.1002","volume":"27","author":[{"given":"Yu\u2010Huan","family":"Geng","sequence":"first","affiliation":[{"name":"College of Chemistry and Institute of Green Catalysis Zhengzhou University  No. 100, Science Road Zhengzhou City Henan province 450000 P. 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