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Conversely, their derivatives 6\u2010cyano\u20107\u2010azidoquinoline <jats:bold>(6CN\u22127N<jats:sub>3<\/jats:sub>Q<\/jats:bold>) and 3\u2010cyano\u20107\u2010azidoquinoline (<jats:bold>3CN\u22127N<jats:sub>3<\/jats:sub>Q<\/jats:bold>) show virtually no emission, which makes them suitable to be used as recognition agents in azide reactions based on fluorescence recovery. Moreover, conjugation of <jats:bold>6CN\u22127AQ<\/jats:bold> with a hydrophobic biomembrane\u2010penetration peptide PFVYLI renders a nearly non\u2010emissive <jats:bold>6CN\u22127AQ\u2010PFVYLI<\/jats:bold> composite, which can be digested by proteinase K, recovering the highly emissive <jats:bold>6CN\u22127AQ<\/jats:bold> with \u223c200\u2010fold enhancement. The result provides an effective early confirmation for RT\u2010qPCR in viral detection.<\/jats:p>","DOI":"10.1002\/chem.202100413","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T15:02:58Z","timestamp":1619535778000},"page":"8040-8047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cyano Derivatives of 7\u2010Aminoquinoline That Are Highly Emissive in Water: Potential for Sensing Applications"],"prefix":"10.1002","volume":"27","author":[{"given":"Kai\u2010Hsin","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Chemistry National Taiwan University  Taipei 10617 Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Chih","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Taiwan University  Taipei 10617 Taiwan, 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