{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:18:07Z","timestamp":1789129087990,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["FLIX, 862179"],"award-info":[{"award-number":["FLIX, 862179"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2021,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel ruthenium\u2010catalyzed C\u2212H activation methodology for hydrogen isotope exchange of aromatic carbonyl compounds is presented. In the presence of catalytic amounts of specific amine additives, a transient directing group is formed <jats:italic>in\u2005situ<\/jats:italic>, which directs selective deuteration. A high degree of deuteration is achieved for <jats:italic>\u03b1\u2010<\/jats:italic>carbonyl and aromatic <jats:italic>ortho\u2010<\/jats:italic>positions. In addition, appropriate choice of conditions allows for exclusive labeling of the <jats:italic>\u03b1\u2010<\/jats:italic>carbonyl position while a procedure for the preparation of merely <jats:italic>ortho<\/jats:italic>\u2010deuterated compounds is also reported. This methodology proceeds with good functional group tolerance and can be also applied for deuteration of pharmaceutical drugs. Mechanistic studies reveal a kinetic isotope effect of 2.2, showing that the C\u2212H activation is likely the rate\u2010determining step of the catalytic cycle. Using deuterium oxide as a cheap and convenient source of deuterium, the methodology presents a cost\u2010efficient alternative to state\u2010of\u2010the\u2010art iridium\u2010catalyzed procedures.<\/jats:p>","DOI":"10.1002\/chem.202100468","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T15:44:58Z","timestamp":1618242298000},"page":"9768-9773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ruthenium\u2010Catalyzed Deuteration of Aromatic Carbonyl Compounds with a Catalytic Transient Directing Group"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-9396","authenticated-orcid":false,"given":"Sara","family":"Kopf","sequence":"first","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse e. 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