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These silylated heterocycles are readily transformed into 6\u2010aryl\u2010indolo[3,2\u2010<jats:italic>a<\/jats:italic>]phenazines in moderate to good yield by one\u2010pot <jats:italic>ipso<\/jats:italic>\u2010iodination Suzuki coupling. The title compounds represent a novel type of tunable luminophore. Structure\u2010property relationships for 6\u2010aryl\u2010indolo[3,2\u2010<jats:italic>a<\/jats:italic>]phenazines obtained from Hammett correlations with <jats:italic>\u03c3<\/jats:italic><jats:sub><jats:italic>p+<\/jats:italic><\/jats:sub> substituent parameters indicate that emission maxima, Stokes shifts, and fluorescence quantum yields can be fine\u2010tuned by the remote <jats:italic>para<\/jats:italic>\u2010aryl substituent. Furthermore, indolo[3,2\u2010<jats:italic>a<\/jats:italic>]phenazines were found to exhibit interesting activities against medically relevant pathogens such as the Apicomplexa parasite <jats:italic>Toxoplasma gondii<\/jats:italic> with an IC<jats:sub>50<\/jats:sub> of up to 0.67\u00b10.13\u2005\u03bcM. Thus, these compounds are promising candidates for novel anti\u2010parasitic therapies.<\/jats:p>","DOI":"10.1002\/chem.202101391","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T23:28:42Z","timestamp":1619047722000},"page":"9774-9781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fluorescent Indolo[3,2\u2010<i>a<\/i>]phenazines against <i>Toxoplasma gondii<\/i>: Concise Synthesis by Gold\u2010Catalyzed Cycloisomerization with 1,2\u2010Silyl Migration and <i>ipso<\/i>\u2010Iodination Suzuki Sequence"],"prefix":"10.1002","volume":"27","author":[{"given":"Franziska K.","family":"Merkt","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Makromolekulare Chemie Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf  Universit\u00e4tsstra\u00dfe 1 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaminia","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Krankenhaushygiene Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf  Universit\u00e4tsstra\u00dfe 1 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabnam Shaneh","family":"Sazzadeh","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Krankenhaushygiene Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf  Universit\u00e4tsstra\u00dfe 1 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorand","family":"Bonda","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie und Makromolekulare Chemie Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf  Universit\u00e4tsstra\u00dfe 1 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa K. 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