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The reaction is promoted by copper(II) acetate in dichloromethane at 40\u2009\u00b0C under oxygen in the presence of diisopropylethylamine and 1,10\u2010phenanthroline and allows the transfer of aryl groups with substituents at any position of the aromatic ring. The reaction shows excellent functional group tolerance and is applicable to dipeptides where the histidine is located at the N terminus. A histidine\u2010guided backbone N\u2212H arylation was observed in dipeptides where the histidine occupies the C terminus.<\/jats:p>","DOI":"10.1002\/chem.202102186","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T09:48:14Z","timestamp":1628243294000},"page":"13330-13336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Copper\u2010Promoted N\u2010Arylation of the Imidazole Side Chain of Protected Histidine by Using Triarylbismuth Reagents"],"prefix":"10.1002","volume":"27","author":[{"given":"Hwai\u2010Chien","family":"Chan","sequence":"first","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al D\u00e9partement de chimie  C.P. 8888, Succursale Centre-Ville Montr\u00e9al Qu\u00e9bec H3C 3P8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Bueno","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al D\u00e9partement de chimie  C.P. 8888, Succursale Centre-Ville Montr\u00e9al Qu\u00e9bec H3C 3P8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Le Roch","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al D\u00e9partement de chimie  C.P. 8888, Succursale Centre-Ville Montr\u00e9al Qu\u00e9bec H3C 3P8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-0936","authenticated-orcid":false,"given":"Alexandre","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al D\u00e9partement de chimie  C.P. 8888, Succursale Centre-Ville Montr\u00e9al Qu\u00e9bec H3C 3P8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.609"},{"key":"e_1_2_2_2_1","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666171003113540"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2014.999672"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190915258"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.95"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr980425s"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","first-page":"1","volume":"4","author":"Gagnon A.","year":"2018","journal-title":"Sci. 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