{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:15:08Z","timestamp":1789748108106,"version":"4.0.1"},"reference-count":75,"publisher":"Wiley","issue":"59","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["G-2420-302.5\/2016"],"award-info":[{"award-number":["G-2420-302.5\/2016"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010134","name":"Evonik Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GA 2362\/2-1"],"award-info":[{"award-number":["GA 2362\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 20876\/294-1 FUGG"],"award-info":[{"award-number":["INST 20876\/294-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this contribution we report on the synthesis, characterization and application of water\u2010soluble zinc(II) phthalocyanines, which are decorated with four or eight umbelliferone moieties for photodynamic therapy (PDT). These compounds are linked peripherally to zinc(II) phthalocyanine by a triethylene glycol linker attached to pyridines, leading to cationic pyridinium units, able to increase the water solubility of the system. Beside their photophysical properties they were analyzed concerning their cellular distribution in human hepatocyte carcinoma (HepG2) cells as well as their phototoxicity towards HepG2 cells, Gram\u2010positive (<jats:italic>S. aureus<\/jats:italic> strain 3150\/12 and <jats:italic>B. subtilis<\/jats:italic> strain DB104) and Gram\u2010negative bacteria (<jats:italic>E. coli<\/jats:italic> strain UTI89 and <jats:italic>E. coli<\/jats:italic> strain Nissle 1917). At low light doses and concentrations, they exhibit superb antimicrobial activity against Gram\u2010positive bacteria as well as anti\u2010tumor activity against HepG2. They are even capable to inactivate Gram\u2010negative bacteria, whereas the dark toxicity remains low. These unique water\u2010soluble compounds can be regarded as all\u2010in\u2010one type photosensitizers with broad applications ranges in the future.<\/jats:p>","DOI":"10.1002\/chem.202102255","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T09:24:47Z","timestamp":1627550687000},"page":"14672-14680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Umbelliferone Decorated Water\u2010soluble Zinc(II) Phthalocyanines \u2013 <i>In Vitro<\/i> Phototoxic Antimicrobial Anti\u2010cancer Agents"],"prefix":"10.1002","volume":"27","author":[{"given":"Andrea","family":"Sowa","sequence":"first","affiliation":[{"name":"Institute of Chemistry (Organic chemistry) University of Duisburg-Essen  Universit\u00e4tsstra\u00dfe 7 45117 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"H\u00f6ing","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology II Center for Medical Biotechnology (ZMB) University of Duisburg-Essen  Universit\u00e4tsstrasse 5 45117 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Dobrindt","sequence":"additional","affiliation":[{"name":"Institute of Hygiene Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster  Mendelstra\u00dfe 7 48149 M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley K.","family":"Knauer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology II Center for Medical Biotechnology (ZMB) University of Duisburg-Essen  Universit\u00e4tsstrasse 5 45117 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzhela","family":"Galstyan","sequence":"additional","affiliation":[{"name":"Center for Soft Nanoscience Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster  Busso-Peus-Stra\u00dfe 10 48149 M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Voskuhl","sequence":"additional","affiliation":[{"name":"Institute of Chemistry (Organic chemistry) University of Duisburg-Essen  Universit\u00e4tsstra\u00dfe 7 45117 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201703398"},{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201703398"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902837"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200902837"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2007.08.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.27_18-RA-01"},{"key":"e_1_2_6_5_1","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01529-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01299"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.049"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.05.016"},{"key":"e_1_2_6_10_1","unstructured":"\u00a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/62\/5\/R1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2017.09.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC03065A"},{"key":"e_1_2_6_15_1","first-page":"158","volume":"03","author":"Rosa L. P.","year":"2014","journal-title":"J. Med. Microb. Diagn."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB01357H"},{"key":"e_1_2_6_17_1","unstructured":"\u00a0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119595"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202002703"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/cs9952400019"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma9919110"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5004198"},{"key":"e_1_2_6_23_1","unstructured":"\u00a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b02611"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2sm27353e"},{"key":"e_1_2_6_26_1","first-page":"140","volume":"1","author":"Liu Y.","year":"2015","journal-title":"J. Clin. Transl. Res."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201704562"},{"key":"e_1_2_6_28_1","unstructured":"\u00a0"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2008.09.016"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22060994"},{"key":"e_1_2_6_31_1","unstructured":"\u00a0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-016-0655-7"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.2823"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/963248"},{"key":"e_1_2_6_35_1","unstructured":"\u00a0"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402401"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2011.08.045"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2011.05.023"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2011.07.003"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2011.11.014"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2012.03.009"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1142\/S108842461550087X"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2012.08.080"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2015.10.026"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2019.05.004"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-13-12816"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2012.04.034"},{"key":"e_1_2_6_48_1","unstructured":"\u00a0"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/pola.21615"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja060593z"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2007.05.008"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070781f"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1993-25825"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/b802709a"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b02132"},{"key":"e_1_2_6_56_1","unstructured":"\u00a0"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp054778o"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2014.11.073"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.3184\/174751916X14579698644727"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2011.07.014"},{"key":"e_1_2_6_61_1","unstructured":"\u00a0"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-016-2792-4"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.synthmet.2010.05.025"},{"key":"e_1_2_6_64_1","unstructured":"\u00a0"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2016.04.026"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2013.08.025"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1973.743"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1409(199803\/04)2:2<145::AID-JPP60>3.0.CO;2-2"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201504935"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111787"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2011.05.048"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.05.008"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01341D"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202102255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202102255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202102255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:24:00Z","timestamp":1760286240000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202102255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":75,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2021,10,21]]}},"alternative-id":["10.1002\/chem.202102255"],"URL":"https:\/\/doi.org\/10.1002\/chem.202102255","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}