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However, developments of the NIR\u2010IIa fluorophores are still facing considerable challenges. In this work, a series of diketopyrrolopyrrole (DPP)\u2010based fluorophores were designed and synthesized. Subsequently, nanomaterial <jats:bold>T25@F127<\/jats:bold> with significant NIR\u2010IIa emission properties was rationally prepared by encapsulating DPP\u2010based fluorophore <jats:bold>T25<\/jats:bold>, and was selected for fluorescence angiography and cerebral vascular microscopic imaging with nearly 800\u2005\u03bcm penetrating depth and excellent signal\u2010background ratio of 4.07 and 2.26 (at 250 and 400\u2005\u03bcm), respectively. Furthermore, the nanomaterial <jats:bold>T25@cRGD<\/jats:bold> with tumor targeting ability can image tiny metastatic tumor on intestine with a small size of 0.3\u2005mm\u00d71.0\u2005mm and high\u2010spatial resolution (SBR=3.84). This study demonstrates that the nanomaterials which encapsulated <jats:bold>T25<\/jats:bold> behave as excellent NIR\u2010IIa fluorescence imaging agents and have a great potential for in\u2005vivo biological application.<\/jats:p>","DOI":"10.1002\/chem.202102312","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T22:59:56Z","timestamp":1627858796000},"page":"14240-14249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Small\u2010Molecule Diketopyrrolopyrrole\u2010Based Dye for in\u2005vivo NIR\u2010IIa Fluorescence Bioimaging"],"prefix":"10.1002","volume":"27","author":[{"given":"Zhicheng","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Materials Joint International Research Laboratory for Precision Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology  130 Meilong Road Shanghai 200237 P. 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